Description

6-Fluoronicotinic Acid (CAS No. 403-45-2) is a high-purity fluorinated nicotinic acid derivative with the molecular formula C₆H₄FNO₂. This fine chemical is a versatile building block in pharmaceutical and agrochemical research, offering a unique combination of fluorine substitution and carboxylic acid functionality. As a white to off-white crystalline powder, it is characterized by excellent solubility in polar organic solvents and moderate stability under standard laboratory conditions. Our product is synthesized under strict quality control protocols, ensuring >97% purity by HPLC analysis. Ideal for coupling reactions, metal-catalyzed cross-couplings, and heterocyclic chemistry applications. Each batch undergoes rigorous analytical characterization including ¹H/¹⁹F NMR, FTIR, and mass spectrometry verification. Packaged in amber glass vials with argon headspace for optimal stability.

Properties

• CAS Number: 403-45-2
• Complexity: 140
• IUPAC Name: 6-fluoropyridine-3-carboxylic acid
• InChI: InChI=1S/C6H4FNO2/c7-5-2-1-4(3-8-5)6(9)10/h1-3H,(H,9,10)
• InChI Key: UJDLCTNVHJEBDG-UHFFFAOYSA-N
• Exact Mass: 141.02260653
• Molecular Formula: C6H4FNO2
• Molecular Weight: 141.10
• SMILES: C1=CC(=NC=C1C(=O)O)F
• Topological: 50.2
• Monoisotopic Mass: 141.02260653
• Synonyms: 6-Fluoronicotinic acid, DTXSID80287610, DTXCID30238758, 637-033-0, 403-45-2, 6-Fluoropyridine-3-carboxylic acid, 2-fluoropyridine-5-carboxylic acid, 2-Fluoro-5-pyridinecarboxylic Acid, 6-fluoro-3-pyridinecarboxylic acid, MFCD01859863, 6-Fluoronicotinicacid, NSC51767, 6-fluoro nicotinic acid, 6-fluoro-nicotinic acid, SCHEMBL646556, 6-fluoropyridine-3-formic acid, CHEMBL247112, 2-fluoro-pyridine-5-carboxylic acid, 6-fluoro-pyridine-3-carboxylic acid, 2-Fluoro-5-pyridine carboxylic acid, BBL103748, NSC-51767, SBB065228, STL557558, AKOS005254427, AB09999, CS-W019722, FF35006, PS-9025, AC-18825, SY004391, 6-Fluoropyridine-3-carboxylic acid, 97%, DB-005395, F0695, EN300-75668, Z1182395505, 6-Fluoropyridine-3-carboxylic acid; 2-Fluoropyridine-5-carboxylic acid

6-Fluoronicotinic Acid serves as a key intermediate in medicinal chemistry for developing novel kinase inhibitors and CNS-active compounds. The fluorine substituent enhances metabolic stability in drug candidates while the carboxylic acid group enables amide bond formation. Researchers utilize this compound in Suzuki-Miyaura couplings to create biaryl pharmacophores. It also finds application in synthesizing fluorinated analogs of nicotinic acid derivatives for agricultural chemicals. The electron-withdrawing fluorine atom makes this building block particularly valuable for designing electron-deficient heterocycles.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.