Description

6-Fluoro-1-indanone (CAS No. 1481-32-9) is a high-purity fluorinated organic compound with the molecular formula C₉H₇FO and IUPAC name 6-fluoro-2,3-dihydroinden-1-one. This versatile building block is widely used in pharmaceutical research, agrochemical synthesis, and material science applications. The compound features a fluoro-substituted indanone core structure, offering unique electronic and steric properties for advanced synthetic transformations.

Our product is rigorously tested to ensure ≥98% purity (by GC/HPLC) and is supplied as a white to off-white crystalline powder. It is packaged under inert atmosphere to ensure stability and long shelf life. Ideal for use in Suzuki couplings, Grignard reactions, and other organometallic transformations.

Key specifications:

• Molecular Weight: 150.15 g/mol
• Melting Point: 45-48°C
• Boiling Point: 250-252°C
• Density: 1.25 g/cm³
• Storage: 2-8°C under nitrogen

Properties

• CAS Number: 1481-32-9
• Complexity: 178
• IUPAC Name: 6-fluoroindan-1-one
• InChI: InChI=1S/C9H7FO/c10-7-3-1-6-2-4-9(11)8(6)5-7/h1,3,5H,2,4H2
• InChI Key: LVUUCFIQQHEFEJ-UHFFFAOYSA-N
• Exact Mass: 150.048093005
• Molecular Formula: C9H7FO
• Molecular Weight: 150.15
• SMILES: C1CC(=O)C2=C1C=CC(=C2)F
• Topological: 17.1
• Monoisotopic Mass: 150.048093005
• Synonyms: 6-Fluoro-1-indanone, 1481-32-9, DTXSID30364046, DTXCID70315092, 625-201-6, 6-fluoro-2,3-dihydroinden-1-one, 6-fluoro-2,3-dihydro-1H-inden-1-one, 1H-Inden-1-one, 6-fluoro-2,3-dihydro-, 6-fluoroindan-1-one, MFCD01318147, 6-Fluoro-indan-1-one, 6fluoro-1-indanone, 6-Fluoro-1-indanone, 96%, SCHEMBL1150109, LVUUCFIQQHEFEJ-UHFFFAOYSA-N, BCP04453, SBB056321, AKOS005206718, AB08649, AC-9650, DS-0573, BP-10962, SY010637, TS-01973, CS-0001933, F0668, ST50824204, EN300-84437, 1H-?Inden-?1-?one, 6-?fluoro-?2,?3-?dihydro-, Z814904728

Application

6-Fluoro-1-indanone serves as a key intermediate in the synthesis of bioactive molecules, particularly in developing CNS-active pharmaceuticals. Researchers utilize this compound in the preparation of fluorinated analogs of important drug scaffolds. The fluoro-substitution enhances metabolic stability and bioavailability in candidate compounds. This building block is particularly valuable in medicinal chemistry programs targeting serotonin and dopamine receptors.

Safety and Hazards

GHS Hazard Statements

• H302 (87%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (15.2%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (15.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (13%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (87%)
• Skin Irrit. 2 (15.2%)
• Eye Irrit. 2A (15.2%)
• STOT SE 3 (13%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.