Description

6-Chloroguanosine (CAS No. 2004-07-1) is a high-purity nucleoside analog with the molecular formula C₁₀H₁₂ClN₅O₄. This compound is a modified guanosine derivative, where the 6-position of the purine ring is substituted with a chlorine atom. It is widely utilized in biochemical research, particularly in studies involving nucleic acid metabolism, enzymatic processes, and antiviral or anticancer drug development. With a purity of ≥95%, our 6-Chloroguanosine is rigorously tested for quality and consistency, ensuring reliable performance in sensitive applications such as PCR, nucleotide synthesis, and enzyme inhibition assays. Available in various quantities, this product is ideal for researchers requiring precise and reproducible results in molecular biology and pharmaceutical sciences.

Properties

• CAS Number: 2004-07-1
• Complexity: 367
• IUPAC Name: (2R,3R,4S,5R)-2-(2-amino-6-chloro-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
• InChI: InChI=1S/C10H12ClN5O4/c11-7-4-8(15-10(12)14-7)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6-,9-/m1/s1
• InChI Key: TXWHPSZYRUHEGT-UUOKFMHZSA-N
• Exact Mass: 301.0577816
• Molecular Formula: C10H12ClN5O4
• Molecular Weight: 301.69
• SMILES: C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N=C(N=C2Cl)N
• Topological: 140
• Monoisotopic Mass: 301.0577816
• Synonyms: 6-Chloroguanosine, 2004-07-1, 6-Chloroguanine riboside, 6-Chloroguanineriboside, (2R,3R,4S,5R)-2-(2-Amino-6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol, 9H-Purin-2-amine, 6-chloro-9-beta-D-ribofuranosyl-, (2R,3R,4S,5R)-2-(2-amino-6-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol, MFCD00005735, 2-Amino-6-chloropurine-9-riboside, 2-Amino-6-chloro-9-(beta-D-ribofuranosyl)purine, 6-Chloro-9-(Beta-D-Ribofuranosyl)-9h-Purin-2-Amine, (-)-2-Amino-6-chloropurine riboside, (2R,3R,4S,5R)-2-(2-amino-6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol, (3S,2R,4R,5R)-5-(2-amino-6-chloropurin-9-yl)-2-(hydroxymethyl)oxolane-3,4-diol, 6-Chloro-9-beta-D-ribofuranosyl-9H-purin-2-amine, 9h-purin-2-amine, 6-chloro-9-|A-d-ribofuranosyl-, SCHEMBL637420, CHEMBL244169, 2-Amino-6-chloropurine ribosid, EINECS 217-905-3, NSC 44586, SBB002967, 2-Amino-6-chloropurine Ribonucleoside, AKOS015854915, AKOS015896934, GS-3225, 2-Amino-6-chloropurine-9-?-D-riboside, ST057088, 2-Amino-6-chloropurine riboside, >=95%, NS00045737, EN300-1704270, 6-chloro-2-amino-9-(beta-D-ribofuranosyl)purine, 2-Amino-6-chloropurine riboside (6-Chloroguanosine), 2-amino-6-chloro-9-(beta-d-ribofuranosyl)-9h-purine, Q27456329, (4S,2R,3R,5R)-2-[2-amino-6-chloro-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol, 6CR

6-Chloroguanosine is primarily used as a nucleoside analog in biochemical and pharmacological research. It serves as a substrate or inhibitor in studies of purine metabolism and enzyme kinetics, particularly for nucleoside phosphorylases and kinases. This compound is also employed in the development of antiviral and anticancer agents due to its ability to interfere with nucleic acid synthesis. Additionally, it finds applications in structural biology for crystallographic and NMR studies of nucleoside-binding proteins.

Safety and Hazards

GHS Hazard Statements

• H315 (66.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (66.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (66.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (66.7%)
• Eye Irrit. 2A (66.7%)
• STOT SE 3 (66.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.