Description

6-Chloro-4-methylpyridine-3-carboxylic acid (CAS No. 503555-50-8) is a high-purity heterocyclic carboxylic acid derivative with the molecular formula C₇H₆ClNO₂. This compound features a chloro-substituted pyridine ring with a methyl group at the 4-position and a carboxylic acid moiety at the 3-position, making it a versatile building block for pharmaceutical and agrochemical synthesis. With a molecular weight of 171.58 g/mol, it is supplied as a white to off-white crystalline powder with ≥95% purity (HPLC). Ideal for researchers in medicinal chemistry, this intermediate is rigorously tested for impurities (≤0.5% by GC) and is packaged under inert gas to ensure stability. Available in quantities from 1g to 1kg with customizable bulk options.

Properties

• CAS Number: 503555-50-8
• Complexity: 163
• IUPAC Name: 6-chloro-4-methyl-pyridine-3-carboxylic acid
• InChI: InChI=1S/C7H6ClNO2/c1-4-2-6(8)9-3-5(4)7(10)11/h2-3H,1H3,(H,10,11)
• InChI Key: ZCLFIXIHOWGYDY-UHFFFAOYSA-N
• Exact Mass: 171.0087061
• Molecular Formula: C7H6ClNO2
• Molecular Weight: 171.58
• SMILES: CC1=CC(=NC=C1C(=O)O)Cl
• Topological: 50.2
• Monoisotopic Mass: 171.0087061
• Synonyms: 503555-50-8, 6-Chloro-4-methylpyridine-3-carboxylic acid, DTXSID80624460, DTXCID50575213, 689-861-7, 6-Chloro-4-methylnicotinic acid, 6-Chloro-4-methyl-3-pyridinecarboxylic acid, 4-METHYL-6-CHLORONICOTINIC ACID, MFCD12755871, 2-CHLORO-4-METHYLPYRIDINE-5-CARBOXYLIC ACID, 6-Chloro-4-methyl-pyridine-3-carboxylic acid, 6-Chloro-4-methyl-3-pyridinecarboxylic acid;2-Chloro-4-methylpyridine-5-carboxylic acid, 3-PYRIDINECARBOXYLIC ACID, 6-CHLORO-4-METHYL-, 6-Chloro-4-methyl-3-pyridinecarboxylicacid, SCHEMBL3752864, ZCLFIXIHOWGYDY-UHFFFAOYSA-N, DVA55550, CS1635, AKOS015935052, AB65755, CS-W007037, PS-8685, SY022650, EN300-97674, Z1255416862, 6-Chloro-4-methylpyridine-3-carboxylic acid, 5-Carboxy-2-chloro-4-methylpyridine

Application

6-Chloro-4-methylpyridine-3-carboxylic acid serves as a key intermediate in the synthesis of biologically active compounds, particularly in the development of kinase inhibitors and antimicrobial agents. Its reactive carboxylic acid group enables facile derivatization for structure-activity relationship (SAR) studies in drug discovery. The compound is also utilized in material science for constructing functionalized pyridine-based ligands in coordination chemistry.

Safety and Hazards

GHS Hazard Statements

• H301 (25%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (25%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (75%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (75%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (25%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (75%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (25%)
• Acute Tox. 4 (50%)
• Acute Tox. 4 (25%)
• Skin Irrit. 2 (75%)
• Eye Irrit. 2A (75%)
• Acute Tox. 4 (25%)
• STOT SE 3 (75%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.