Description

6-Chloro-2-methylpyridine-3-carboxylic acid (CAS No. 137129-98-7) is a high-purity, fine chemical compound with the molecular formula C₇H₆ClNO₂. This heterocyclic carboxylic acid features a chloro-substituted pyridine ring with a methyl group at the 2-position and a carboxyl group at the 3-position, making it a versatile intermediate in organic synthesis and pharmaceutical research. Its precise molecular weight is 171.58 g/mol, and it is supplied as a white to off-white crystalline powder with ≥95% purity (HPLC). Ideal for researchers and scientists, this compound is rigorously tested for quality, stability, and consistency, ensuring reliable performance in synthetic applications. Store in a cool, dry place, protected from light and moisture to maintain integrity.

Properties

• CAS Number: 137129-98-7
• Complexity: 163
• IUPAC Name: 6-chloro-2-methyl-pyridine-3-carboxylic acid
• InChI: InChI=1S/C7H6ClNO2/c1-4-5(7(10)11)2-3-6(8)9-4/h2-3H,1H3,(H,10,11)
• InChI Key: SGHDEIVHYSOLRC-UHFFFAOYSA-N
• Exact Mass: 171.0087061
• Molecular Formula: C7H6ClNO2
• Molecular Weight: 171.58
• SMILES: CC1=C(C=CC(=N1)Cl)C(=O)O
• Topological: 50.2
• Monoisotopic Mass: 171.0087061
• Synonyms: 137129-98-7, 6-Chloro-2-methylpyridine-3-carboxylic acid, DTXSID60673138, DTXCID30623887, 692-770-5, 6-Chloro-2-methylnicotinic acid, 3-PYRIDINECARBOXYLIC ACID, 6-CHLORO-2-METHYL-, MFCD09842452, 6-chloro-2-methyl-3-pyridinecarboxylic acid, Chloro-2-methylnicotinic acid, SCHEMBL398966, 6-Chloro-2-methylnicotinicacid, 2-methyl-6-chloronicotinic acid, SGHDEIVHYSOLRC-UHFFFAOYSA-N, BCP14859, AKOS006310448, AB53710, AG-0216, CS-W006084, SY022648, DB-359401, EN300-93422, Z1198234546

Application

6-Chloro-2-methylpyridine-3-carboxylic acid is widely used as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. Its reactive carboxyl and chloro groups enable facile derivatization for building complex heterocyclic scaffolds. Researchers employ it in medicinal chemistry for drug discovery, particularly in developing kinase inhibitors and antimicrobial agents. It also serves as a precursor for ligands and catalysts in asymmetric synthesis.

Safety and Hazards

GHS Hazard Statements

• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (50%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (50%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (50%)
• Acute Tox. 4 (50%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (50%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.