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Atomfair 6-Chloro-2-iodo-3-methoxypyridine C6H5ClINO CAS 1256790-05-2

6-Chloro-2-iodo-3-methoxypyridine (CAS No. 1256790-05-2) is a high-purity halogenated pyridine derivative with the molecular formula C6H5ClINO . This compound is a valuable heterocyclic building block for pharmaceutical and agrochemical research, featuring both chloro and iodo substituents on a methoxy-functionalized pyridine ring. Its unique structure enables versatile reactivity in cross-coupling reactions (e.g., Suzuki, Stille) , nucleophilic substitutions, and metal-catalyzed transformations. Supplied as a crystalline solid with ≥95% purity (HPLC), it is rigorously tested by GC/MS, NMR, and elemental analysis to ensure batch-to-batch consistency. Ideal for medicinal chemistry applications, this intermediate is packaged under inert gas in amber glass vials to ensure stability.…

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Description

6-Chloro-2-iodo-3-methoxypyridine (CAS No. 1256790-05-2) is a high-purity halogenated pyridine derivative with the molecular formula C6H5ClINO. This compound is a valuable heterocyclic building block for pharmaceutical and agrochemical research, featuring both chloro and iodo substituents on a methoxy-functionalized pyridine ring. Its unique structure enables versatile reactivity in cross-coupling reactions (e.g., Suzuki, Stille), nucleophilic substitutions, and metal-catalyzed transformations. Supplied as a crystalline solid with ≥95% purity (HPLC), it is rigorously tested by GC/MS, NMR, and elemental analysis to ensure batch-to-batch consistency. Ideal for medicinal chemistry applications, this intermediate is packaged under inert gas in amber glass vials to ensure stability. Synonyms include DTXSID10857320 and DTXCID80808061.

Properties

  • CAS Number: 1256790-05-2
  • Complexity: 114
  • IUPAC Name: 6-chloro-2-iodo-3-methoxy-pyridine
  • InChI: InChI=1S/C6H5ClINO/c1-10-4-2-3-5(7)9-6(4)8/h2-3H,1H3
  • InChI Key: SYDPZCLUEAZSMB-UHFFFAOYSA-N
  • Exact Mass: 268.91044
  • Molecular Formula: C6H5ClINO
  • Molecular Weight: 269.47
  • SMILES: COC1=C(N=C(C=C1)Cl)I
  • Topological: 22.1
  • Monoisotopic Mass: 268.91044
  • Synonyms: 6-CHLORO-2-IODO-3-METHOXYPYRIDINE, 1256790-05-2, DTXSID10857320, DTXCID80808061, 102-880-2, 6-Chloro-2-iodo-3-methoxy-pyridine, MFCD18255029, SCHEMBL18512255, GAC79005, AKOS026741270, SB21303, AS-41846, SY149015, DB-129494, CS-0144080, EN300-125863

Application

6-Chloro-2-iodo-3-methoxypyridine serves as a key intermediate in the synthesis of biologically active molecules, particularly in drug discovery for kinase inhibitors and CNS-targeting compounds. Its iodo substituent facilitates palladium-catalyzed cross-coupling reactions to construct complex heteroaromatic scaffolds. Researchers utilize this compound in structure-activity relationship (SAR) studies due to its dual halogen functionality, enabling selective derivatization. It is also employed in the development of agrochemicals and fluorescent probes.

Safety and Hazards

GHS Hazard Statements

  • H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
  • H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (100%)
  • Skin Irrit. 2 (100%)
  • Eye Dam. 1 (100%)
  • STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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