Description

6-Bromonicotinic Acid (CAS No. 6311-35-9) is a high-purity brominated derivative of nicotinic acid, widely used as a key intermediate in pharmaceutical synthesis, agrochemical research, and material science applications. With the molecular formula C₆H₄BrNO₂, this white to off-white crystalline powder offers exceptional reactivity for coupling reactions, metal-catalyzed cross-coupling (e.g., Suzuki, Stille), and heterocyclic building block construction. Its bromo and carboxylic acid functional groups enable versatile derivatization, making it invaluable for drug discovery (e.g., kinase inhibitors) and ligand design. Packaged under inert conditions to ensure stability, our ≥96% pure product is rigorously tested via HPLC, NMR, and MS to meet the stringent requirements of research and industrial workflows. Available in grams to kilogram quantities with optional custom purity and packaging.

Properties

• CAS Number: 6311-35-9
• Complexity: 140
• IUPAC Name: 6-bromopyridine-3-carboxylic acid
• InChI: InChI=1S/C6H4BrNO2/c7-5-2-1-4(3-8-5)6(9)10/h1-3H,(H,9,10)
• InChI Key: JDJBRMNTXORYEN-UHFFFAOYSA-N
• Exact Mass: 200.94254
• Molecular Formula: C6H4BrNO2
• Molecular Weight: 202.01
• SMILES: C1=CC(=NC=C1C(=O)O)Br
• Topological: 50.2
• Monoisotopic Mass: 200.94254
• Synonyms: 6-Bromonicotinic acid, 6311-35-9, 6-Bromopyridine-3-carboxylic acid, 6-Bromo Nicotinic Acid, 2-bromopyridine-5-carboxylic acid, 6-bromo-3-pyridinecarboxylic acid, 2-bromo-5-pyridinecarboxylic acid, 3-Pyridinecarboxylic acid, 6-bromo-, MFCD01927100, 2-bromo-5-pyridine carboxylic acid, NSC-43545, 6-Bromonicotinicacid, 6-bromo-3-pyridine carboxylic acid, NSC43545, 6-bromo-nicotinic acid, SCHEMBL38414, 6R7N3FA49W, CHEMBL3236912, DTXSID30286037, BCP22188, STR08711, SBB028530, AKOS000320219, AC-2756, CS-W002864, FB11254, HY-W002864, PB18554, PS-3093, 6-Bromopyridine-3-carboxylic acid, 96%, SY002819, DB-031377, B2961, ST50826535, EN300-86132, AI-942/13331025, F1926-0006, Z1258919772

6-Bromonicotinic acid serves as a critical precursor in medicinal chemistry for synthesizing bioactive molecules, particularly kinase inhibitors and antiviral agents. Its reactive bromine atom facilitates palladium-catalyzed cross-coupling to introduce nicotinic acid scaffolds into complex structures. Researchers also employ it in coordination chemistry to design metal-organic frameworks (MOFs) and catalysts. In agrochemical development, it aids in creating herbicidal and pesticidal compounds with enhanced selectivity.

Safety and Hazards

GHS Hazard Statements

• H302 (90.2%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (98%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (90.2%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (98%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.