Description

6-Bromo-3-fluoro-2-methylpyridine (CAS No. 374633-38-2) is a high-purity halogenated pyridine derivative with the molecular formula C₆H₅BrFN. This compound is a valuable building block in pharmaceutical and agrochemical research, offering versatile reactivity for cross-coupling reactions, nucleophilic substitutions, and metal-catalyzed transformations. Its unique structure, featuring bromo and fluoro substituents on a methylated pyridine ring, enables precise molecular modifications in drug discovery and material science. Available in >95% purity (HPLC), it is supplied in rigorously tested batches with full NMR, MS, and HPLC analytical data. Store under inert conditions at 2-8°C to ensure stability.

Properties

• CAS Number: 374633-38-2
• Complexity: 99.1
• IUPAC Name: 6-bromo-3-fluoro-2-methyl-pyridine
• InChI: InChI=1S/C6H5BrFN/c1-4-5(8)2-3-6(7)9-4/h2-3H,1H3
• InChI Key: BFQONZCQHGIKIY-UHFFFAOYSA-N
• Exact Mass: 188.95894
• Molecular Formula: C6H5BrFN
• Molecular Weight: 190.01
• SMILES: CC1=C(C=CC(=N1)Br)F
• Topological: 12.9
• Monoisotopic Mass: 188.95894
• Synonyms: 374633-38-2, 6-Bromo-3-fluoro-2-methylpyridine, DTXSID90958561, DTXCID901386464, 675-596-4, 2-Bromo-5-fluoro-6-methylpyridine, 2-bromo-5-fluoro-6-picoline, 2-Bromo-5-fluoro-6-methyl pyridine, PYRIDINE, 6-BROMO-3-FLUORO-2-METHYL-, 374633-88-2, 6-Bromo-3-fluoro-2-methyl-pyridine, MFCD03095064, 6-Bromo-3-fluoro-2-picoline, 6-BROMO-3-FLUOROPICOLINE, 5-Fluoro-6-methyl-2-bromopyridine, 6-BroMo-3-fluoro-2-Methyl pyridine, SCHEMBL588633, SCHEMBL18132256, BFQONZCQHGIKIY-UHFFFAOYSA-N, BCP22149, SBB091031, AKOS005257288, AB13446, AC-5414, CS-W008966, FB55478, GS-6806, SB20874, 6-bromanyl-3-fluoranyl-2-methyl-pyridine, SY019950, DB-020661, DB-260843, EN300-85399, 6-Bromo-3-fluoro-2-methylpyridine, AldrichCPR, A823675, 2-Bromo-5-fluoro-6-picoline;6-Bromo-3-fluoro-2-methylpyridine, 2-Bromo-5-fluoro-6-methylpyridine;6-Bromo-3-fluoro-2-methylpyridine

Application

6-Bromo-3-fluoro-2-methylpyridine serves as a key intermediate in the synthesis of biologically active molecules, particularly in the development of kinase inhibitors and antimicrobial agents. Its bromo and fluoro groups facilitate Suzuki-Miyaura and Buchwald-Hartwig couplings for aryl-aryl bond formation. Researchers utilize this compound to introduce methylpyridine motifs into complex scaffolds for structure-activity relationship (SAR) studies. It is also employed in radiolabeling and PET tracer synthesis due to its halogen reactivity.

Safety and Hazards

GHS Hazard Statements

• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (16.7%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (33.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (66.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (16.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (50%)
• Acute Tox. 4 (16.7%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (33.3%)
• Eye Irrit. 2A (66.7%)
• Acute Tox. 4 (16.7%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.