Description

6-Bromo-2-chloropyridin-3-amine (CAS No. 169833-70-9) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₄BrClN₂. This versatile heterocyclic compound features both bromo and chloro substituents on its pyridine ring, along with an amine functional group, making it a valuable intermediate in pharmaceutical and agrochemical synthesis. With a molecular weight of 207.46 g/mol, this off-white to light yellow crystalline powder offers excellent solubility in organic solvents like DMSO and methanol. Our product is rigorously tested to ensure ≥95% purity (HPLC) and is supplied in sealed containers under inert atmosphere to guarantee stability. Ideal for cross-coupling reactions, nucleophilic substitutions, and as a building block for complex N-heterocycles, this compound is a must-have for medicinal chemistry and material science research.

Properties

• CAS Number: 169833-70-9
• Complexity: 101
• IUPAC Name: 6-bromo-2-chloro-pyridin-3-amine
• InChI: InChI=1S/C5H4BrClN2/c6-4-2-1-3(8)5(7)9-4/h1-2H,8H2
• InChI Key: YCECOMBEVDPUJG-UHFFFAOYSA-N
• Exact Mass: 205.92464
• Molecular Formula: C5H4BrClN2
• Molecular Weight: 207.45
• SMILES: C1=CC(=NC(=C1N)Cl)Br
• Topological: 38.9
• Monoisotopic Mass: 205.92464
• Synonyms: 6-bromo-2-chloropyridin-3-amine, 169833-70-9, DTXSID40365983, DTXCID40317023, 696-449-0, 3-Amino-6-bromo-2-chloropyridine, MFCD04971930, 6-bromo-2-chloro-3-pyridylamine, F1926-0002, SCHEMBL857644, 6-bromo-2-chloro-3-pyridinamine, YCECOMBEVDPUJG-UHFFFAOYSA-N, 6-bromo-2-chloro-3-pyridinylamine, SMSSF-0044205, SBB038997, STL227624, AKOS000267429, AB20901, CS-W003207, PS-5231, AC-27482, SY031476, DB-064756, A2967, ST45174491, 6-Bromo-2-chloropyridin-3-amine, AldrichCPR, EN300-81015, 10.14272/YCECOMBEVDPUJG-UHFFFAOYSA-N.1, AC-907/34114024, doi:10.14272/YCECOMBEVDPUJG-UHFFFAOYSA-N.1

Application

6-Bromo-2-chloropyridin-3-amine serves as a key synthetic intermediate in the preparation of pharmaceutical compounds, particularly in the development of kinase inhibitors and antimicrobial agents. Its reactive halogen sites enable efficient Suzuki-Miyaura and Buchwald-Hartwig coupling reactions for constructing complex heterocyclic systems. Researchers utilize this compound in the synthesis of potential drug candidates targeting central nervous system disorders and inflammatory diseases.

Safety and Hazards

GHS Hazard Statements

• H302 (75%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (75%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (75%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (75%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (75%)
• Acute Tox. 4 (75%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (75%)
• STOT SE 3 (75%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.