Description

(5R)-(+)-2,2,3-Trimethyl-5-benzyl-4-imidazolidinone monohydrochloride (CAS No. 323196-43-6) is a high-purity chiral imidazolidinone derivative with the molecular formula C₁₃H₁₉ClN₂O. This compound features a stereogenic center at the 5-position (R-configuration) and is supplied as a monohydrochloride salt for enhanced stability and solubility. Its rigid imidazolidinone scaffold, substituted with benzyl and methyl groups, makes it a valuable intermediate in asymmetric synthesis and pharmaceutical research. The product is characterized by >98% purity (HPLC) and is available in sealed packaging under inert conditions to ensure long-term integrity. Ideal for use in organocatalysis, peptidomimetics, and medicinal chemistry applications requiring enantioselective control.

Properties

• CAS Number: 323196-43-6
• Complexity: 269
• IUPAC Name: (5R)-5-benzyl-2,2,3-trimethyl-imidazolidin-4-one;hydrochloride
• InChI: InChI=1S/C13H18N2O.ClH/c1-13(2)14-11(12(16)15(13)3)9-10-7-5-4-6-8-10;/h4-8,11,14H,9H2,1-3H3;1H/t11-;/m1./s1
• InChI Key: YIYFEXGDFJLJGM-RFVHGSKJSA-N
• Exact Mass: 254.1185909
• Molecular Formula: C13H19ClN2O
• Molecular Weight: 254.75
• SMILES: CC1(N[C@@H](C(=O)N1C)CC2=CC=CC=C2)C.Cl
• Topological: 32.3
• Monoisotopic Mass: 254.1185909
• Synonyms: 323196-43-6, (5R)-(+)-2,2,3-Trimethyl-5-benzyl-4-imidazolidinone monohydrochloride, 625-207-9, (R)-5-Benzyl-2,2,3-trimethylimidazolidin-4-one hydrochloride, (5R)-2,2,3-Trimethyl-5-phenylmethyl-4-imidazolidinone monohydrochloride, (5R)-5-benzyl-2,2,3-trimethylimidazolidin-4-one;hydrochloride, MFCD08276839, SCHEMBL3191316, (5R)-(+)-2,2,3-Trimethyl-5-benzyl-4-imidazolidinone hydrochloride, AKOS015901364, BS-16866, D82970, (R)-5-Benzyl-2,2,3-trimethylimidazolidin-4-one HCl, (R)-5-Benzyl-2,2,3-trimethylimidazolidin-4-onehydrochloride, (5R)-(+)-2,2,3-Trimethyl-5-benzyl-4-imidazolidinone monohydrochloride, 97%

Application

This chiral imidazolidinone derivative is widely employed as a key building block in the synthesis of enantiomerically pure pharmaceuticals and agrochemicals. It serves as a precursor for asymmetric organocatalysts, particularly in Michael additions and Diels-Alder reactions. Researchers also utilize it in the development of peptidomimetic compounds targeting protease enzymes. The hydrochloride salt form improves handling characteristics for solid-phase synthesis applications.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.5%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.