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Atomfair 5-(Trifluoromethyl)oxolan-2-one C5H5F3O2 CAS 1547-45-1

5-(Trifluoromethyl)oxolan-2-one (CAS No. 1547-45-1) is a high-purity fluorinated heterocyclic compound with the molecular formula C5H5F3O2. This specialized chemical features a trifluoromethyl group attached to a γ-lactone (oxolan-2-one) ring, offering unique reactivity and stability for advanced synthetic applications. It is supplied as a clear, colorless to pale yellow liquid with ≥98% purity (GC), ideal for precision research. Suitable for use as a fluorinated building block in pharmaceuticals, agrochemicals, and materials science. Store under inert atmosphere at 2-8°C to maintain stability. Available in research (1g, 5g) and bulk quantities (25g, 100g, custom).

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Description

5-(Trifluoromethyl)oxolan-2-one (CAS No. 1547-45-1) is a high-purity fluorinated heterocyclic compound with the molecular formula C5H5F3O2. This specialized chemical features a trifluoromethyl group attached to a γ-lactone (oxolan-2-one) ring, offering unique reactivity and stability for advanced synthetic applications. It is supplied as a clear, colorless to pale yellow liquid with ≥98% purity (GC), ideal for precision research. Suitable for use as a fluorinated building block in pharmaceuticals, agrochemicals, and materials science. Store under inert atmosphere at 2-8°C to maintain stability. Available in research (1g, 5g) and bulk quantities (25g, 100g, custom).

Properties

  • CAS Number: 1547-45-1
  • Complexity: 151
  • IUPAC Name: 5-(trifluoromethyl)tetrahydrofuran-2-one
  • InChI: InChI=1S/C5H5F3O2/c6-5(7,8)3-1-2-4(9)10-3/h3H,1-2H2
  • InChI Key: GNKPTBKNJXNUTC-UHFFFAOYSA-N
  • Exact Mass: 154.02416388
  • Molecular Formula: C5H5F3O2
  • Molecular Weight: 154.09
  • SMILES: C1CC(=O)OC1C(F)(F)F
  • Topological: 26.3
  • Monoisotopic Mass: 154.02416388
  • Synonyms: 5-(trifluoromethyl)oxolan-2-one, 1547-45-1, 978-879-3, 5-(trifluoromethyl)dihydrofuran-2(3H)-one, SCHEMBL2038475, SCHEMBL2043539, SCHEMBL12182879, AKOS040803447, EN300-180314

Application

5-(Trifluoromethyl)oxolan-2-one serves as a key intermediate in the synthesis of trifluoromethylated bioactive molecules, particularly in pharmaceutical development where the CF3 group enhances metabolic stability. It is utilized in asymmetric catalysis for chiral lactone derivatives and as a precursor for fluorinated polymers with tailored dielectric properties. Researchers employ this compound to study ring-opening reactions under nucleophilic conditions.

Safety and Hazards

GHS Hazard Statements

  • H227 (100%): Combustible liquid [Warning Flammable liquids]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P210, P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403, P403+P233, P405, and P501

Hazard Classes and Categories

  • Flam. Liq. 4 (100%)
  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2A (100%)
  • STOT SE 3 (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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