Description

(5-Methylthiophen-2-yl)boronic acid (CAS No. 162607-20-7) is a high-purity boronic acid derivative with the molecular formula C₅H₇BO₂S. This heterocyclic compound features a thiophene ring substituted with a methyl group at the 5-position and a boronic acid moiety at the 2-position, making it a versatile building block for Suzuki-Miyaura cross-coupling reactions. Ideal for pharmaceutical, agrochemical, and materials science research, this reagent is supplied as a white to off-white crystalline powder with ≥95% purity (HPLC). Store under inert conditions at 2-8°C to ensure stability. Suitable for use in organic synthesis, catalysis, and as a ligand in metal-organic frameworks (MOFs).

Properties

• CAS Number: 162607-20-7
• Complexity: 99
• IUPAC Name: (5-methyl-2-thienyl)boronic acid
• InChI: InChI=1S/C5H7BO2S/c1-4-2-3-5(9-4)6(7)8/h2-3,7-8H,1H3
• InChI Key: NRIYPIBRPGAWDD-UHFFFAOYSA-N
• Exact Mass: 142.0259808
• Molecular Formula: C5H7BO2S
• Molecular Weight: 141.99
• SMILES: B(C1=CC=C(S1)C)(O)O
• Topological: 68.7
• Monoisotopic Mass: 142.0259808
• Synonyms: (5-methylthiophen-2-yl)boronic Acid, 5-Methyl-2-thiopheneboronic acid, 672-308-9, 5-Methylthiophene-2-boronic acid, 162607-20-7, (5-methyl-2-thienyl)boronic acid, 5-Methyl-2-thienylboronic Acid, MFCD01318166, 5-methyl-2-thienylboric acid, 5-Methyl-2-thiopheneboronic acid (contains varying amounts of Anhydride), 5-methylthiophen-2-ylboronic acid, 5-methylthiophen-2yl-boronic acid, Boronic acid, (5-methyl-2-thienyl)-, (5-methyl-2-thiophenyl)boronic acid, 2-METHYLTHIOPHENE-5-BORONIC ACID, 5-methylthiopheneboronic acid, SCHEMBL130322, 5-methylthiophene boronic acid, 5-methylthiophen-2-boronic acid, DTXSID90370264, 2-methyl-thiophene-5-boronic acid, 5-methyl-2-thiophene-boronic acid, 5-methyl-thiophene-2-boronic acid, 5-methylthiophene-2-ylboronic acid, (5-methylthiophen-2-yl)boronicAcid, BCP27051, 5-methyl-thiophen-2-yl-boronic acid, SBB004150, AKOS003585334, CS-W001235, PB21738, PS-9501, SY004158, DB-009561, M1850, ST50823760, EN300-140712, A810390, Z1203159464, 5-Methyl-2-thienylboric acid; 5-Methyl-2-thienylboronic acid

Application

(5-Methylthiophen-2-yl)boronic acid is widely used in palladium-catalyzed cross-coupling reactions to synthesize biaryl and heteroaryl compounds for drug discovery. It serves as a key intermediate in the development of thiophene-based pharmaceuticals and organic electronic materials. Researchers also employ it in the preparation of sensors and functional polymers due to its robust reactivity and structural versatility.

Safety and Hazards

GHS Hazard Statements

• H302 (11.1%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (11.1%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (11.1%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (88.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (11.1%)
• Acute Tox. 4 (11.1%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (11.1%)
• STOT SE 3 (88.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.