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Atomfair 5-Methoxyspiro[2.3]hexan-1-amine hydrochloride C7H14ClNO CAS 2137780-65-3

5-Methoxyspiro[2.3]hexan-1-amine hydrochloride (CAS No. 2137780-65-3) is a high-purity organic compound with the molecular formula C7H14ClNO . This spirocyclic amine derivative features a unique structural motif, combining a methoxy-substituted spiro[2.3]hexane ring with an amine hydrochloride functional group. The compound is supplied as a white to off-white crystalline powder with ≥95% purity (HPLC). It is soluble in polar organic solvents such as methanol, ethanol, and DMSO, but has limited solubility in water. This building block is particularly valuable for medicinal chemistry research and pharmaceutical development due to its constrained spirocyclic architecture, which can impart improved metabolic stability and target selectivity in drug…

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Description

5-Methoxyspiro[2.3]hexan-1-amine hydrochloride (CAS No. 2137780-65-3) is a high-purity organic compound with the molecular formula C7H14ClNO. This spirocyclic amine derivative features a unique structural motif, combining a methoxy-substituted spiro[2.3]hexane ring with an amine hydrochloride functional group. The compound is supplied as a white to off-white crystalline powder with ≥95% purity (HPLC). It is soluble in polar organic solvents such as methanol, ethanol, and DMSO, but has limited solubility in water. This building block is particularly valuable for medicinal chemistry research and pharmaceutical development due to its constrained spirocyclic architecture, which can impart improved metabolic stability and target selectivity in drug candidates. The hydrochloride salt form ensures enhanced stability and handling characteristics. Store at 2-8°C in a tightly sealed container under inert atmosphere for optimal shelf life.

Properties

  • CAS Number: 2137780-65-3
  • Complexity: 129
  • IUPAC Name: 5-methoxyspiro[2.3]hexan-2-amine;hydrochloride
  • InChI: InChI=1S/C7H13NO.ClH/c1-9-5-2-7(3-5)4-6(7)8;/h5-6H,2-4,8H2,1H3;1H
  • InChI Key: OLKPSFNVVPOENM-UHFFFAOYSA-N
  • Exact Mass: 163.0763918
  • Molecular Formula: C7H14ClNO
  • Molecular Weight: 163.64
  • SMILES: COC1CC2(C1)CC2N.Cl
  • Topological: 35.3
  • Monoisotopic Mass: 163.0763918
  • Synonyms: 5-methoxyspiro[2.3]hexan-1-amine hydrochloride, 2137780-65-3, 5-methoxyspiro(2.3)hexan-1-amine hydrochloride, 847-709-9, 5-methoxyspiro[2.3]hexan-2-amine;hydrochloride, MKD78065, AKOS034087306, EN300-816124, Z2941510753

Application

5-Methoxyspiro[2.3]hexan-1-amine hydrochloride serves as a versatile scaffold in drug discovery, particularly for central nervous system (CNS) targets due to its ability to cross the blood-brain barrier. The spirocyclic structure makes it valuable for developing novel GPCR modulators and enzyme inhibitors with improved pharmacological profiles. Researchers utilize this compound as a key intermediate in the synthesis of potential therapeutics for neurological disorders and psychiatric conditions. Its constrained geometry also facilitates exploration of three-dimensional chemical space in fragment-based drug design.

Safety and Hazards

GHS Hazard Statements

  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2A (100%)
  • STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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