Description

5-Fluorosalicylic Acid (CAS No. 345-16-4) is a fluorinated derivative of salicylic acid with the molecular formula C₇H₅FO₃. This high-purity compound, also known as 5-fluoro-2-hydroxybenzoic acid, is a versatile building block in organic synthesis and pharmaceutical research. It features a carboxylic acid and a hydroxyl group on a benzene ring, with a fluorine substituent at the 5-position, offering unique reactivity for derivatization.

Our 5-Fluorosalicylic Acid is rigorously tested for quality, ensuring ≥98% purity (HPLC) and optimal performance in research applications. It is supplied as a white to off-white crystalline powder with a molecular weight of 156.11 g/mol. Suitable for use in medicinal chemistry, material science, and biochemical studies, this compound is packaged under inert conditions to guarantee stability.

Key applications include its use as a precursor for fluorinated pharmaceuticals, agrochemicals, and specialty polymers. Store in a cool, dry place away from light and moisture. For research use only.

Properties

• CAS Number: 345-16-4
• Complexity: 160
• IUPAC Name: 5-fluoro-2-hydroxy-benzoic acid
• InChI: InChI=1S/C7H5FO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,(H,10,11)
• InChI Key: JWPRICQKUNODPZ-UHFFFAOYSA-N
• Exact Mass: 156.02227218
• Molecular Formula: C7H5FO3
• Molecular Weight: 156.11
• SMILES: C1=CC(=C(C=C1F)C(=O)O)O
• Topological: 57.5
• Monoisotopic Mass: 156.02227218
• Synonyms: 5-Fluorosalicylic acid, 345-16-4, 5-Fluoro-2-hydroxybenzoic acid, Benzoic acid, 5-fluoro-2-hydroxy-, 2-Hydroxy-5-fluorobenzoic acid, GDQ70COQ4K, EINECS 206-455-3, UNII-GDQ70COQ4K, NSC-46619, TAVABOROLE METABOLITE M6A, DTXSID00188054, NSC 46619, 5-FSA, DTXCID30110545, inchi=1/c7h5fo3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9h,(h,10,11, MFCD00002456, CHEMBL229239, 5-fluoro-2-hydroxy-benzoic acid, 5Fluorosalicylic acid, 5-fluoro-salicylic acid, SCHEMBL130520, 5-Fluorosalicylic acid, 97%, SCHEMBL27515038, 2-hydroxy-5-fluoro-benzoic acid, 5-fluoro-2-hydroxy benzoic acid, NSC46619, BBL100293, BDBM50219484, CK2251, SBB066006, STL553863, AKOS005254826, AC-7550, CS-W016245, FF38767, PS-8850, ST094905, SY007435, DB-048634, F0469, NS00042347, EN300-49122, Z367679206

Application

5-Fluorosalicylic Acid is widely used as an intermediate in the synthesis of fluorinated pharmaceuticals, including nonsteroidal anti-inflammatory drugs (NSAIDs) and antimicrobial agents. Its unique structure enables incorporation into bioactive molecules to enhance metabolic stability and binding affinity. Researchers also employ it in material science for designing fluorinated polymers with tailored properties. Additionally, it serves as a key scaffold in medicinal chemistry for probing enzyme interactions due to its hydrogen-bonding capabilities.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (98%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (98%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.