Description

5-Fluoro-2-(trifluoromethyl)benzyl alcohol (CAS No. 238742-82-0) is a high-purity fluorinated benzyl alcohol derivative with the molecular formula C₈H₆F₄O. This compound, also known by its IUPAC name [5-fluoro-2-(trifluoromethyl)phenyl]methanol, is a versatile building block in organic synthesis and pharmaceutical research. Its unique structure, featuring both fluorine and trifluoromethyl substituents, enhances its reactivity and utility in nucleophilic substitutions, coupling reactions, and as a precursor for advanced intermediates. Ideal for medicinal chemistry applications, this product is rigorously tested for purity and stability, ensuring reliable performance in demanding research environments. Available in various quantities to suit laboratory-scale and bulk requirements.

Properties

• CAS Number: 238742-82-0
• Complexity: 168
• IUPAC Name: [5-fluoro-2-(trifluoromethyl)phenyl]methanol
• InChI: InChI=1S/C8H6F4O/c9-6-1-2-7(8(10,11)12)5(3-6)4-13/h1-3,13H,4H2
• InChI Key: AGVUJWYLCSOJDS-UHFFFAOYSA-N
• Exact Mass: 194.03547746
• Molecular Formula: C8H6F4O
• Molecular Weight: 194.13
• SMILES: C1=CC(=C(C=C1F)CO)C(F)(F)F
• Topological: 20.2
• Monoisotopic Mass: 194.03547746
• Synonyms: 5-Fluoro-2-(trifluoromethyl)benzyl alcohol, 238742-82-0, [5-fluoro-2-(trifluoromethyl)phenyl]methanol, (5-Fluoro-2-(trifluoromethyl)phenyl)methanol, 2-trifluoromethyl-5-fluorobenzyl alcohol, [5-fluoro-2-(trifluoromethyl)phenyl]methan-1-ol, MFCD00236286, SCHEMBL21403423, DTXSID70372145, AGVUJWYLCSOJDS-UHFFFAOYSA-N, CK2482, SBB091694, AKOS005216948, PS-8300, DB-046276, CS-0193269, ST50407118, EN300-1929674

Application

5-Fluoro-2-(trifluoromethyl)benzyl alcohol is widely used as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty materials. Its fluorinated aromatic structure makes it valuable for developing bioactive compounds with enhanced metabolic stability and lipophilicity. Researchers utilize this compound in cross-coupling reactions, esterifications, and as a precursor for heterocyclic frameworks. It is particularly relevant in the design of CNS-targeting drugs and fluorinated liquid crystals.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.