Description

5-Fluoro-2-methylpyridine (CAS No. 31181-53-0) is a high-purity fluorinated pyridine derivative with the molecular formula C₆H₆FN. This heterocyclic compound is widely utilized in pharmaceutical, agrochemical, and materials science research due to its unique reactivity as a building block for complex organic synthesis. The presence of both fluorine and methyl substituents on the pyridine ring enhances its utility in nucleophilic aromatic substitution and metal-catalyzed coupling reactions. Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied in sealed, light-resistant packaging under inert atmosphere to guarantee stability. Available in quantities from grams to multi-kilogram scale, it is ideal for medicinal chemistry, ligand design, and specialty chemical applications.

Key Specifications:
– CAS: 31181-53-0
– Molecular Weight: 111.12 g/mol
– Appearance: Colorless to pale yellow liquid
– Boiling Point: ~145-148°C
– Density: ~1.1 g/cm³
– Storage: 2-8°C under nitrogen

Properties

• CAS Number: 31181-53-0
• Complexity: 74.9
• IUPAC Name: 5-fluoro-2-methyl-pyridine
• InChI: InChI=1S/C6H6FN/c1-5-2-3-6(7)4-8-5/h2-4H,1H3
• InChI Key: LXAHHHIGZXPRKQ-UHFFFAOYSA-N
• Exact Mass: 111.048427358
• Molecular Formula: C6H6FN
• Molecular Weight: 111.12
• SMILES: CC1=NC=C(C=C1)F
• Topological: 12.9
• Monoisotopic Mass: 111.048427358
• Synonyms: 5-fluoro-2-methylpyridine, 31181-53-0, DTXSID10376521, DTXCID20327549, 814-475-4, 5-fluoro-2-picoline, 3-Fluoro-6-picoline, 3-fluoro-6-methylpyridine, MFCD03095271, 5-fluoro-2-methyl-pyridine, PYRIDINE, 5-FLUORO-2-METHYL-, 5-Fluoro -2-picoline, SCHEMBL424656, SCHEMBL754139, SCHEMBL932697, SCHEMBL1439318, SCHEMBL16114306, SCHEMBL22978495, LXAHHHIGZXPRKQ-UHFFFAOYSA-N, BCP05119, AKOS005146144, AC-5403, CS-W006280, PB18589, PS-9260, SY003227, DB-031412, EN300-42353, 5-Fluoro-2-methylpyridine (5-Fluoro-2-picoline)

Application

5-Fluoro-2-methylpyridine serves as a versatile intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders and oncology. Its electron-deficient pyridine core facilitates the development of kinase inhibitors and PET radiotracer precursors. In agrochemical research, it functions as a key scaffold for novel pesticides and herbicides. The compound’s fluorine moiety also enables its use in material science for designing liquid crystals and conductive polymers.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (50%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (50%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.