Description
5-Fluoro-2-methoxypyridine (CAS No. 51173-04-7) is a high-purity fluorinated pyridine derivative with the molecular formula C6H6FNO. This compound is a versatile building block in pharmaceutical and agrochemical synthesis, offering excellent reactivity for nucleophilic substitution and cross-coupling reactions. Its methoxy and fluorine substituents enhance its utility in the development of active pharmaceutical ingredients (APIs) and specialty chemicals. Available in >98% purity (GC), it is supplied in rigorously tested batches with detailed analytical certificates (COA). Suitable for research, process development, and scale-up applications under inert conditions. Packaged in amber glass bottles or sealed drums under nitrogen to ensure stability.
Properties
- CAS Number: 51173-04-7
- Complexity: 89.1
- IUPAC Name: 5-fluoro-2-methoxy-pyridine
- InChI: InChI=1S/C6H6FNO/c1-9-6-3-2-5(7)4-8-6/h2-4H,1H3
- InChI Key: GYGABXVZIHADCT-UHFFFAOYSA-N
- Exact Mass: 127.043341977
- Molecular Formula: C6H6FNO
- Molecular Weight: 127.12
- SMILES: COC1=NC=C(C=C1)F
- Topological: 22.1
- Monoisotopic Mass: 127.043341977
- Synonyms: 5-fluoro-2-methoxypyridine, 51173-04-7, DTXSID10382485, DTXCID30333510, 675-599-0, 2-Methoxy-5-fluoropyridine, MFCD03095252, PYRIDINE, 5-FLUORO-2-METHOXY-, 5-Fluoro-2-methoxy-pyridine, 5-fluoro-2-methoxy pyridine, SCHEMBL361334, SCHEMBL1449320, SCHEMBL1526233, SCHEMBL1736269, SCHEMBL14675978, GYGABXVZIHADCT-UHFFFAOYSA-N, BCP22119, BBL103088, SBB085672, STL556898, AKOS005063678, AB13611, DS-1620, PS-9165, AC-24933, SY013020, DB-027665, CS-0007509, EN300-50145
Application
5-Fluoro-2-methoxypyridine is widely used as a key intermediate in the synthesis of fluorinated heterocycles for drug discovery, particularly in kinase inhibitors and CNS-targeting compounds. Its electron-deficient pyridine ring facilitates palladium-catalyzed coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig transformations. Researchers also employ it in the development of agrochemicals and advanced materials due to its stability and regioselectivity.
Safety and Hazards
GHS Hazard Statements
- H226 (77.8%): Flammable liquid and vapor [Warning Flammable liquids]
- H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
- H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
- H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statements
- P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501
Hazard Classes and Categories
- Flam. Liq. 3 (77.8%)
- Skin Irrit. 2 (100%)
- Eye Irrit. 2A (100%)
- STOT SE 3 (100%)
If you are interested or have any questions, please contact us at support@atomfair.com
Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.


Reviews
There are no reviews yet.