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Atomfair 5-Fluoro-2-methoxypyridine C6H6FNO CAS 51173-04-7

5-Fluoro-2-methoxypyridine (CAS No. 51173-04-7) is a high-purity fluorinated pyridine derivative with the molecular formula C6H6FNO . This compound is a versatile building block in pharmaceutical and agrochemical synthesis, offering excellent reactivity for nucleophilic substitution and cross-coupling reactions. Its methoxy and fluorine substituents enhance its utility in the development of active pharmaceutical ingredients (APIs) and specialty chemicals. Available in >98% purity (GC), it is supplied in rigorously tested batches with detailed analytical certificates (COA). Suitable for research, process development, and scale-up applications under inert conditions. Packaged in amber glass bottles or sealed drums under nitrogen to ensure stability.

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Description

5-Fluoro-2-methoxypyridine (CAS No. 51173-04-7) is a high-purity fluorinated pyridine derivative with the molecular formula C6H6FNO. This compound is a versatile building block in pharmaceutical and agrochemical synthesis, offering excellent reactivity for nucleophilic substitution and cross-coupling reactions. Its methoxy and fluorine substituents enhance its utility in the development of active pharmaceutical ingredients (APIs) and specialty chemicals. Available in >98% purity (GC), it is supplied in rigorously tested batches with detailed analytical certificates (COA). Suitable for research, process development, and scale-up applications under inert conditions. Packaged in amber glass bottles or sealed drums under nitrogen to ensure stability.

Properties

  • CAS Number: 51173-04-7
  • Complexity: 89.1
  • IUPAC Name: 5-fluoro-2-methoxy-pyridine
  • InChI: InChI=1S/C6H6FNO/c1-9-6-3-2-5(7)4-8-6/h2-4H,1H3
  • InChI Key: GYGABXVZIHADCT-UHFFFAOYSA-N
  • Exact Mass: 127.043341977
  • Molecular Formula: C6H6FNO
  • Molecular Weight: 127.12
  • SMILES: COC1=NC=C(C=C1)F
  • Topological: 22.1
  • Monoisotopic Mass: 127.043341977
  • Synonyms: 5-fluoro-2-methoxypyridine, 51173-04-7, DTXSID10382485, DTXCID30333510, 675-599-0, 2-Methoxy-5-fluoropyridine, MFCD03095252, PYRIDINE, 5-FLUORO-2-METHOXY-, 5-Fluoro-2-methoxy-pyridine, 5-fluoro-2-methoxy pyridine, SCHEMBL361334, SCHEMBL1449320, SCHEMBL1526233, SCHEMBL1736269, SCHEMBL14675978, GYGABXVZIHADCT-UHFFFAOYSA-N, BCP22119, BBL103088, SBB085672, STL556898, AKOS005063678, AB13611, DS-1620, PS-9165, AC-24933, SY013020, DB-027665, CS-0007509, EN300-50145

Application

5-Fluoro-2-methoxypyridine is widely used as a key intermediate in the synthesis of fluorinated heterocycles for drug discovery, particularly in kinase inhibitors and CNS-targeting compounds. Its electron-deficient pyridine ring facilitates palladium-catalyzed coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig transformations. Researchers also employ it in the development of agrochemicals and advanced materials due to its stability and regioselectivity.

Safety and Hazards

GHS Hazard Statements

  • H226 (77.8%): Flammable liquid and vapor [Warning Flammable liquids]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

  • Flam. Liq. 3 (77.8%)
  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2A (100%)
  • STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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