Description

5-Fluoro-2-methoxyphenylboronic acid (CAS No. 179897-94-0) is a high-purity boronic acid derivative with the molecular formula C₇H₈BFO₃. This compound is a versatile building block in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions, enabling the formation of biaryl structures with high efficiency. The presence of both fluoro and methoxy substituents on the phenyl ring enhances its reactivity and selectivity in coupling reactions. Ideal for pharmaceutical, agrochemical, and materials science research, this boronic acid is supplied with rigorous quality control to ensure consistency in your experiments. Store in a cool, dry place, protected from moisture to maintain stability.

Properties

• CAS Number: 179897-94-0
• Complexity: 145
• IUPAC Name: (5-fluoro-2-methoxy-phenyl)boronic acid
• InChI: InChI=1S/C7H8BFO3/c1-12-7-3-2-5(9)4-6(7)8(10)11/h2-4,10-11H,1H3
• InChI Key: CCQKIRUMTHHPSX-UHFFFAOYSA-N
• Exact Mass: 170.0550524
• Molecular Formula: C7H8BFO3
• Molecular Weight: 169.95
• SMILES: B(C1=C(C=CC(=C1)F)OC)(O)O
• Topological: 49.7
• Monoisotopic Mass: 170.0550524
• Synonyms: 5-Fluoro-2-methoxyphenylboronic acid, 179897-94-0, (5-fluoro-2-methoxyphenyl)boronic acid, DTXSID70382204, DTXCID00333229, 605-875-8, 5-Fluoro-2-methoxybenzeneboronic acid, 2-methoxy-5-fluorophenylboronic acid, MFCD01863526, Boronic acid, B-(5-fluoro-2-methoxyphenyl)-, Boronic acid, (5-fluoro-2-methoxyphenyl)-, SCHEMBL4572, CCQKIRUMTHHPSX-UHFFFAOYSA-N, ALBB-006118, SBB071077, STK503720, 2-Methoxy-5-fluorophenyl boronic acid, 3-fluoro-6-methoxy-phenylboronic acid, 5-fluoro-2-methoxy phenylboronic acid, 5-fluoro-2-methoxy-phenylboronic acid, 5-fluoro-2-methoxyphenyl boronic acid, 5-fluoro-2-methoxyphenyl-boronic acid, AKOS000266630, 4-FLUOROANISOLE-2-BORONIC ACID, 5-fluoro-2-methoxybenzene boronic acid, AC-5395, AS-2625, 5-fluoro-2-methoxy phenyl boronic acid, 5-fluoro-2-methoxy-phenyl boronic acid, (5-fluoro-2-methoxyphenyl)-boronic acid, 5-fluoro-2-methoxy benzene boronic acid, HY-32924, SY014637, [5-fluoro-2-(methyloxy)phenyl]boronic acid, DB-009558, CS-0007622, F0775, EN300-78438, 5-Fluoro-2-methoxyphenylboronic acid, >=95%, F0001-0653, Z381513692, 5-Fluoro-2-methoxyphenylboronic Acid (contains varying amounts of Anhydride)

Application

5-Fluoro-2-methoxyphenylboronic acid is widely used in pharmaceutical research for the synthesis of fluorinated drug candidates. It serves as a key intermediate in Suzuki-Miyaura cross-coupling reactions to construct complex aromatic systems. The compound is also employed in the development of agrochemicals and functional materials due to its unique electronic properties.

Safety and Hazards

GHS Hazard Statements

• H302 (25%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (16.7%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (91.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (91.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (16.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (83.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (25%)
• Acute Tox. 4 (16.7%)
• Skin Irrit. 2 (91.7%)
• Eye Irrit. 2 (91.7%)
• Acute Tox. 4 (16.7%)
• STOT SE 3 (83.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.