Description

5′-DMT-Ac-rC (CAS No. 121058-82-0) is a high-purity, chemically modified nucleoside derivative designed for advanced oligonucleotide synthesis and research applications. This compound features a 5′-O-(4,4′-dimethoxytrityl) (DMT) protecting group and an N4-acetyl modification on the cytidine base, ensuring precise control during solid-phase synthesis of RNA and modified oligonucleotides. With the molecular formula C₃₂H₃₃N₃O₈, it is characterized by its exceptional stability and compatibility with standard phosphoramidite chemistry protocols. Ideal for researchers in therapeutic development, genomics, and molecular biology, this product is rigorously tested via HPLC and MS to guarantee ≥95% purity. Store desiccated at -20°C for optimal longevity.

Properties

• CAS Number: 121058-82-0
• Complexity: 990
• IUPAC Name: N-[1-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-3,4-dihydroxy-tetrahydrofuran-2-yl]-2-oxo-pyrimidin-4-yl]acetamide
• InChI: InChI=1S/C32H33N3O8/c1-20(36)33-27-17-18-35(31(39)34-27)30-29(38)28(37)26(43-30)19-42-32(21-7-5-4-6-8-21,22-9-13-24(40-2)14-10-22)23-11-15-25(41-3)16-12-23/h4-18,26,28-30,37-38H,19H2,1-3H3,(H,33,34,36,39)/t26-,28-,29-,30-/m1/s1
• InChI Key: AFQGZOMSSIQDMD-PYYPWFDZSA-N
• Exact Mass: 587.22676502
• Molecular Formula: C32H33N3O8
• Molecular Weight: 587.6
• SMILES: CC(=O)NC1=NC(=O)N(C=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O)O
• Topological: 139
• Monoisotopic Mass: 587.22676502
• Synonyms: 121058-82-0, 5′-DMT-Ac-rC, Cytidine, N-acetyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-, 5′-O-(4,4′-DiMethoxytrityl)-N4-acetyl cytidine, N-(1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide, N-[1-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide, N4-Acetyl-5′-O-DMT-cytidine, AFQGZOMSSIQDMD-PYYPWFDZSA-N, C32H33N3O8, MFCD12912693, AKOS024462360, NA11105, AS-56380, W19138, N4-Acetyl-5′-O-(4,4′-dimethoxytrityl)cytidine, N4-Acetyl-5′-O-(4,4′-dimethoxytrityl)-cytidine, 5′-O-(4,4′-Dimethoxytrityl)-N4-acetyl-2′-cytidine, 5/’-O-(4,4/’-Dimethoxytrityl)-N4-acetyl-2/’-deoxycytidine, N4-Acetyl-5??-O-(4,4??-dimethoxytrityl)-2??-deoxycytidine

Application

5′-DMT-Ac-rC is widely used in RNA synthesis as a protected nucleoside building block, particularly for introducing acetylated cytidine modifications. It enables the study of epigenetic regulation and RNA-protein interactions due to its stable acetyl group. Researchers also employ it in antisense oligonucleotide and siRNA development to enhance nuclease resistance and binding affinity.

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