Atomfair 5-(Chloromethyl)-1,2,3-trifluorobenzene 3,4,5-Trifluorobenzyl chloride C7H4ClF3 CAS 732306-27-3

Description

5-(Chloromethyl)-1,2,3-trifluorobenzene (CAS No. 732306-27-3) is a high-purity fluorinated aromatic compound with the molecular formula C₇H₄ClF₃. This versatile intermediate features a chloromethyl group (-CH₂Cl) at the 5-position of a 1,2,3-trifluorobenzene ring, offering unique reactivity for nucleophilic substitution and cross-coupling reactions. The trifluorinated aromatic backbone provides enhanced electron-withdrawing properties and metabolic stability, making it valuable for pharmaceutical and agrochemical synthesis. Available in >98% purity by GC analysis, this compound is supplied in rigorously tested batches with complete analytical data (HPLC, NMR, MS). Suitable for use in organofluorine chemistry, material science, and as a building block for PET radiotracers. Packaged under inert gas in amber glass vials to ensure stability.

Properties

• CAS Number: 732306-27-3
• Complexity: 119
• IUPAC Name: 5-(chloromethyl)-1,2,3-trifluoro-benzene
• InChI: InChI=1S/C7H4ClF3/c8-3-4-1-5(9)7(11)6(10)2-4/h1-2H,3H2
• InChI Key: ALUFGPFDDJIQCW-UHFFFAOYSA-N
• Exact Mass: 179.9953623
• Molecular Formula: C7H4ClF3
• Molecular Weight: 180.55
• SMILES: C1=C(C=C(C(=C1F)F)F)CCl
• Monoisotopic Mass: 179.9953623
• Synonyms: 5-(Chloromethyl)-1,2,3-trifluorobenzene, 732306-27-3, DTXSID60590730, DTXCID10541494, 3,4,5-Trifluorobenzyl chloride, 5-(CHLOROMETHYL)-1,2,3-TRIFLUORO-BENZENE, SCHEMBL1239272, AKOS009461890, AS-64030, DB-074677, G78565, EN300-1964984

Application

5-(Chloromethyl)-1,2,3-trifluorobenzene serves as a key intermediate in the synthesis of fluorinated liquid crystals for display technologies. The compound is particularly valuable in pharmaceutical research for creating trifluoromethyl-containing drug candidates with improved bioavailability. Its reactive chloromethyl group enables facile functionalization to create ligands for catalytic systems or monomers for specialty polymers.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, and P501

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