Description

5-Chloro-2-pyridinol (CAS No. 4214-79-3) is a high-purity organic compound with the molecular formula C₅H₄ClNO and IUPAC name 5-chloro-1H-pyridin-2-one. This versatile heterocyclic building block features a chloro-substituted pyridine ring with a hydroxyl group at the 2-position, making it an essential intermediate in pharmaceutical, agrochemical, and material science research. Our product is rigorously tested to ensure >98% purity (HPLC) and is supplied as a fine white to off-white crystalline powder with excellent batch-to-batch consistency. Suitable for nucleophilic substitution reactions, metal-catalyzed cross-couplings, and as a ligand precursor. Packaged under inert gas in amber glass vials with PTFE-lined caps to ensure stability during shipping and storage. SDS and Certificate of Analysis available upon request.

Properties

• CAS Number: 4214-79-3
• Complexity: 171
• IUPAC Name: 5-chloro-1H-pyridin-2-one
• InChI: InChI=1S/C5H4ClNO/c6-4-1-2-5(8)7-3-4/h1-3H,(H,7,8)
• InChI Key: SZFUWUOHDRMCKD-UHFFFAOYSA-N
• Exact Mass: 128.9981414
• Molecular Formula: C5H4ClNO
• Molecular Weight: 129.54
• SMILES: C1=CC(=O)NC=C1Cl
• Topological: 29.1
• Monoisotopic Mass: 128.9981414
• Synonyms: 5-Chloro-2-hydroxypyridine, 4214-79-3, 5-Chloropyridin-2-ol, 5-Chloro-2-pyridinol, 2-Hydroxy-5-chloropyridine, 2(1H)-Pyridinone, 5-chloro-, 5-Chloro-2(1H)-pyridinone, 5-Chloro-2-pyridone, 5-chloro-1,2-dihydropyridin-2-one, 3-Chloro-6-hydroxypyridine, EINECS 224-146-1, R7A6F5D3KY, 2(1H)-Pyridone, 5-chloro-, DTXSID1022215, 2-PYRIDINOL, 5-CHLORO-, 5-CHLORO-1H-2-PYRIDINONE, 5-CHLORO-2(1H)-PYRIDONE, DTXCID902215, 5-chloropyridin-2(1H)-one, 5-chloro-1H-pyridin-2-one, 5-Chloro-2-pyridol, MFCD00006275, 13466-36-9, ST093059, UNII-R7A6F5D3KY, 5-chloro-2-hydroxy pyridine, 5-chloropyridone, 5-chloropyrid-2-one, 5-chloropyridine-2-ol, 5-chloro-pyrid-2-one, 5-chloro-pyridin-2-ol, 5-chlorohydropyridin-2-one, 5-Chloro-2-hydroxy-pyridine, SCHEMBL246256, SCHEMBL608856, 5-Chloro-2-hydroxypyridine (5-Chloro-2-pyridinol), SCHEMBL1017461, SCHEMBL1196271, SCHEMBL1982498, SCHEMBL6840789, SCHEMBL9098895, SCHEMBL9098933, SCHEMBL9901376, pyridine, 5-chloro-2-hydroxy-, CHEMBL4535875, 5-Chloro-2-hydroxypyridine, 97%, BBL027573, SBB004227, STL146649, AKOS000431448, AKOS002665622, AC-5171, CS-W009538, FC07270, GS-6569, HY-W008822, pyridine, 5-chloro-1,2-dihydro-2-oxo-, SY012331, TS-03566, DB-002224, DB-013276, C1245, EU-0066770, NS00031112, A26151, EN300-114649, I10252, AC-907/25014042, AH-034/32464045, Q27287885, Z2235409237, InChI=1/C5H4ClNO/c6-4-1-2-5(8)7-3-4/h1-3H,(H,7,8, 5-Chloro-2(1h)-pyridinone;2-Pyridinol,6-chloro-(9CI);6-chloropyridone

Application

5-Chloro-2-pyridinol serves as a key synthetic intermediate in the production of neonicotinoid insecticides such as imidacloprid. The compound’s reactive chloro and hydroxyl groups make it valuable for constructing pyridine-based pharmaceutical scaffolds, particularly in antiviral and antibacterial agents. Researchers utilize this heterocycle in metal-organic framework (MOF) synthesis due to its potential as a coordinating ligand. In material science, it finds application as a precursor for functionalized polymers and corrosion inhibitors.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.