Description

Description

5-Chloro-2-methoxypyridine (CAS No. 13473-01-3) is a high-purity heterocyclic organic compound with the molecular formula C₆H₆ClNO. This fine chemical is a versatile intermediate widely used in pharmaceutical synthesis, agrochemical production, and material science research. The compound features a pyridine ring substituted with a chlorine atom at the 5-position and a methoxy group at the 2-position, offering unique reactivity for nucleophilic aromatic substitution and metal-catalyzed coupling reactions.

Our product is supplied as a clear to pale yellow liquid with ??98% purity (GC), rigorously tested by HPLC, GC-MS, and NMR to ensure batch-to-batch consistency. Suitable for use in medicinal chemistry, this building block is particularly valuable for constructing biologically active molecules including kinase inhibitors and antimicrobial agents. The product is packaged under inert gas in amber glass bottles with PTFE-lined caps to ensure stability.

Key Specifications:
– Molecular Weight: 143.57 g/mol
– Boiling Point: 210-212??C
– Density: 1.21 g/cm³
– Refractive Index: n²⁰_D 1.528-1.532
– Storage: 2-8??C under inert atmosphere

Application

5-Chloro-2-methoxypyridine serves as a key synthetic intermediate in pharmaceutical research, particularly for developing kinase inhibitors and CNS-active compounds. The compound’s reactive chlorine and methoxy substituents make it valuable for palladium-catalyzed cross-coupling reactions in medicinal chemistry. Researchers utilize this building block in the synthesis of agrochemicals, including herbicides and fungicides with enhanced activity profiles. Its structural features also facilitate the development of novel materials for organic electronics and coordination chemistry applications.

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