Description

5-Chloro-2-fluoropyridine (CAS No. 1480-65-5) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₃ClFN. This compound is a versatile building block in pharmaceutical and agrochemical synthesis, offering excellent reactivity for nucleophilic aromatic substitution (S_NAr) and cross-coupling reactions. Its unique electronic properties, conferred by the synergistic effects of chlorine and fluorine substituents, make it ideal for designing bioactive molecules and advanced materials. Available in >98% purity (GC), our product undergoes rigorous QC testing (HPLC, NMR) to ensure batch-to-batch consistency. Packaged under inert gas in amber glass vials to prevent degradation. Suitable for medicinal chemistry, ligand design, and as a precursor for fluorinated heterocycles.

Properties

• CAS Number: 1480-65-5
• Complexity: 78.8
• IUPAC Name: 5-chloro-2-fluoro-pyridine
• InChI: InChI=1S/C5H3ClFN/c6-4-1-2-5(7)8-3-4/h1-3H
• InChI Key: ZULRQGBHWBQPFE-UHFFFAOYSA-N
• Exact Mass: 130.9938050
• Molecular Formula: C5H3ClFN
• Molecular Weight: 131.53
• SMILES: C1=CC(=NC=C1Cl)F
• Topological: 12.9
• Monoisotopic Mass: 130.9938050
• Synonyms: 5-Chloro-2-fluoropyridine, 1480-65-5, DTXSID10323333, DTXCID10274452, 628-145-0, 5-Chloro-2-fluoro-pyridine, MFCD04112513, Pyridine, 5-chloro-2-fluoro-, NSC403604, 2-Fluoropyridine-5- chloro-, SCHEMBL406466, SCHEMBL549389, SCHEMBL1727145, SCHEMBL1968473, ZULRQGBHWBQPFE-UHFFFAOYSA-N, 5-Chloro-2-fluoropyridine, 97%, BCP22136, BBL101206, SBB085795, STL555002, AKOS005064088, AB17577, DS-1012, NSC 403604, NSC-403604, PS-9138, AC-24937, DB-025047, C2303, CS-0007508, EN300-87111

Application

5-Chloro-2-fluoropyridine serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and CNS-targeting drugs. The compound’s fluorine moiety enhances metabolic stability in drug candidates, while the chlorine allows for further functionalization via palladium-catalyzed couplings. It’s also employed in crop protection chemical development, where its pyridine core contributes to herbicidal and insecticidal activity. Researchers utilize this building block in material science for creating fluorinated liquid crystals and conductive polymers.

Safety and Hazards

GHS Hazard Statements

• H226 (98.1%): Flammable liquid and vapor [Warning Flammable liquids]
• H302 (92.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (13.5%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H314 (13.5%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H315 (84.6%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (80.8%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H332 (13.5%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (82.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (98.1%)
• Acute Tox. 4 (92.3%)
• Acute Tox. 4 (13.5%)
• Skin Corr. 1B (13.5%)
• Skin Irrit. 2 (84.6%)
• Eye Dam. 1 (80.8%)
• Acute Tox. 4 (13.5%)
• STOT SE 3 (82.7%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.