Description

5-Chloro-2-fluorobenzaldehyde (CAS No. 96515-79-6) is a high-purity aromatic aldehyde with the molecular formula C₇H₄ClFO, widely utilized in pharmaceutical, agrochemical, and material science research. This compound features a benzaldehyde core substituted with chlorine at the 5-position and fluorine at the 2-position, offering unique reactivity for electrophilic aromatic substitution and nucleophilic addition reactions. Its exceptional purity (>98%) ensures consistent performance in synthetic applications, making it a preferred intermediate for constructing complex heterocycles and fluorinated scaffolds. Packaged under inert conditions to prevent degradation, this reagent is ideal for sensitive organometallic and cross-coupling reactions. Available in gram to kilogram quantities with customizable packaging options.

Properties

• CAS Number: 96515-79-6
• Complexity: 129
• IUPAC Name: 5-chloro-2-fluoro-benzaldehyde
• InChI: InChI=1S/C7H4ClFO/c8-6-1-2-7(9)5(3-6)4-10/h1-4H
• InChI Key: WDTUCEMLUHTMCB-UHFFFAOYSA-N
• Exact Mass: 157.9934706
• Molecular Formula: C7H4ClFO
• Molecular Weight: 158.56
• SMILES: C1=CC(=C(C=C1Cl)C=O)F
• Topological: 17.1
• Monoisotopic Mass: 157.9934706
• Synonyms: 5-Chloro-2-fluorobenzaldehyde, 96515-79-6, DTXSID20378576, DTXCID60329603, 642-608-4, MFCD03094518, 2-fluoro-5-chlorobenzaldehyde, 5-Chloro-2-fluoro-benzaldehyde, 3-chloro-6-fluorobenzaldehyde, BENZALDEHYDE, 5-CHLORO-2-FLUORO-, 2-fluoro-5-chloro-benzaldehyde, SCHEMBL42333, 2-fluoro-5-chloro benzaldehyde, SCHEMBL27613550, WDTUCEMLUHTMCB-UHFFFAOYSA-N, BBL029881, CL8373, SBB063766, STL370333, AKOS005255187, AC-3829, CS-W007736, FC64006, PS-8804, SY017708, DB-007005, C3114, ST51041815, EN300-54987, Z819785594

Application

5-Chloro-2-fluorobenzaldehyde serves as a versatile building block in medicinal chemistry for the synthesis of fluorinated drug candidates targeting CNS disorders. It is employed in Suzuki-Miyaura couplings to create biaryl motifs prevalent in kinase inhibitors. The compound’s aldehyde group also facilitates the production of liquid crystal materials for optoelectronic applications.

Safety and Hazards

GHS Hazard Statements

• H302 (83%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (17%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (17%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (14.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H412 (83%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (83%)
• Skin Irrit. 2 (17%)
• Eye Irrit. 2A (17%)
• STOT SE 3 (14.9%)
• Aquatic Chronic 3 (83%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.