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Atomfair 5-Chloro-2-fluoro-4-iodopyridine C5H2ClFIN

Description 5-Chloro-2-fluoro-4-iodopyridine (CAS No. 659731-48-3) is a high-purity halogenated pyridine derivative designed for advanced synthetic applications in pharmaceutical and agrochemical research. This compound features a unique combination of chloro, fluoro, and iodo substituents on the pyridine ring, offering exceptional reactivity for cross-coupling reactions, nucleophilic substitutions, and metal-catalyzed transformations. With a molecular formula of C5H2ClFIN and a molecular weight of 273.43 g/mol, it is supplied as a crystalline solid with ??95% purity (HPLC). Ideal for constructing complex heterocycles, it serves as a versatile building block in medicinal chemistry, particularly for kinase inhibitors and PET radiotracer development. Packaged under inert gas to…

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Description

Description

5-Chloro-2-fluoro-4-iodopyridine (CAS No. 659731-48-3) is a high-purity halogenated pyridine derivative designed for advanced synthetic applications in pharmaceutical and agrochemical research. This compound features a unique combination of chloro, fluoro, and iodo substituents on the pyridine ring, offering exceptional reactivity for cross-coupling reactions, nucleophilic substitutions, and metal-catalyzed transformations. With a molecular formula of C5H2ClFIN and a molecular weight of 273.43 g/mol, it is supplied as a crystalline solid with ??95% purity (HPLC). Ideal for constructing complex heterocycles, it serves as a versatile building block in medicinal chemistry, particularly for kinase inhibitors and PET radiotracer development. Packaged under inert gas to ensure stability, this product is rigorously tested by GC/MS and 1H/13C NMR to meet stringent research standards.

  • CAS No: 659731-48-3
  • Molecular Formula: C5H2ClFIN
  • Molecular Weight: 257.43
  • Exact Mass: 256.89045
  • Monoisotopic Mass: 256.89045
  • IUPAC Name: 5-chloro-2-fluoro-4-iodopyridine
  • SMILES: C1=C(C(=CN=C1F)Cl)I
  • Synonyms: 5-Chloro-2-fluoro-4-iodopyridine, 659731-48-3, DTXSID10619061, DTXCID10569815, 821-379-6

Application

5-Chloro-2-fluoro-4-iodopyridine is a critical intermediate in the synthesis of bioactive molecules, particularly in the development of kinase-targeting pharmaceuticals and radiopharmaceuticals. Its halogen-rich structure enables efficient Suzuki-Miyaura and Stille couplings for aryl-aryl bond formation. Researchers utilize this compound to introduce iodine handles for subsequent 125I/18F labeling in PET tracer design. In agrochemistry, it serves as a precursor for pyridine-based fungicides with enhanced halogen-dependent activity.

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