Description

5-Chloro-2-fluoro-3-methylpyridine (CAS No. 375368-84-6) is a high-purity halogenated pyridine derivative designed for advanced research and industrial applications. With the molecular formula C₆H₅ClFN, this compound features a unique combination of chloro, fluoro, and methyl substituents on its pyridine ring, offering versatile reactivity for synthetic modifications. Its well-defined structure (IUPAC name: 5-chloro-2-fluoro-3-methylpyridine) ensures consistent performance in organometallic couplings, pharmaceutical intermediates, and agrochemical synthesis. Packaged under inert conditions to guarantee stability, this product is ideal for researchers requiring precise heterocyclic building blocks. Available in quantities from milligrams to kilograms, with optional analytical certificates (GC/HPLC, NMR) upon request.

Properties

• CAS Number: 375368-84-6
• Complexity: 99.1
• IUPAC Name: 5-chloro-2-fluoro-3-methyl-pyridine
• InChI: InChI=1S/C6H5ClFN/c1-4-2-5(7)3-9-6(4)8/h2-3H,1H3
• InChI Key: JUDDLKSLYAIQDR-UHFFFAOYSA-N
• Exact Mass: 145.0094550
• Molecular Formula: C6H5ClFN
• Molecular Weight: 145.56
• SMILES: CC1=CC(=CN=C1F)Cl
• Topological: 12.9
• Monoisotopic Mass: 145.0094550
• Synonyms: 5-Chloro-2-fluoro-3-methylpyridine, 375368-84-6, DTXSID10654058, DTXCID80604808, 675-616-1, 5-Chloro-2-fluoro-3-picoline, 2-fluoro-3-methyl-5-chloropyridine, 2-fluoro-5-chloro-3-picoline, 2-fluoro-5-chloro-3-methylpyridine, MFCD03095094, SCHEMBL635255, 5-chloro-2-fluoro–3-picoline, JUDDLKSLYAIQDR-UHFFFAOYSA-N, BCP22093, SBB086438, AKOS005258309, AB13483, AC-5408, DS-0578, SY019985, DB-023655, CS-0210304, O11399, EN300-1067174

Application

5-Chloro-2-fluoro-3-methylpyridine serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders. Its electron-deficient pyridine core facilitates cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) in medicinal chemistry workflows. The compound is also employed in crop protection research as a precursor for novel fungicides and herbicides. Additionally, it finds utility in material science for designing fluorinated ligands in catalytic systems.

Safety and Hazards

GHS Hazard Statements

• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (50%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (50%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (50%)
• Eye Irrit. 2 (50%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.