Description

5-Chloro-2-cyanopyridine (CAS No. 89809-64-3) is a high-purity heterocyclic compound with the molecular formula C₆H₃ClN₂, widely utilized in pharmaceutical and agrochemical research. This fine chemical, also known by its IUPAC name 5-chloropyridine-2-carbonitrile, features a chlorinated pyridine ring with a nitrile functional group at the 2-position, making it a versatile intermediate for nucleophilic substitution and cross-coupling reactions. Our product is rigorously tested to ensure ≥98% purity (HPLC/GC) and is supplied as a white to off-white crystalline powder with excellent batch-to-batch consistency. Ideal for Suzuki-Miyaura couplings, Buchwald-Hartwig aminations, and other palladium-catalyzed transformations. Packaged under inert gas in amber glass bottles to ensure stability, with available quantities ranging from 1g to 1kg scales. SDS and analytical certificates (CoA, NMR, MS) provided with every order.

Properties

• CAS Number: 89809-64-3
• Complexity: 137
• IUPAC Name: 5-chloropyridine-2-carbonitrile
• InChI: InChI=1S/C6H3ClN2/c7-5-1-2-6(3-8)9-4-5/h1-2,4H
• InChI Key: WTHODOKFSYPTKA-UHFFFAOYSA-N
• Exact Mass: 137.9984758
• Molecular Formula: C6H3ClN2
• Molecular Weight: 138.55
• SMILES: C1=CC(=NC=C1Cl)C#N
• Topological: 36.7
• Monoisotopic Mass: 137.9984758
• Synonyms: 5-Chloro-2-cyanopyridine, 89809-64-3, 5-chloro-2-pyridinecarbonitrile, DTXSID90397072, DTXCID90347931, 640-750-1, 5-chloropicolinonitrile, 5-chloropyridine-2-carbonitrile, 6-Cyano-3-chloropyridine, MFCD03788835, 2-Cyano-5-chloro pyridine, 2-Pyridinecarbonitrile, 5-chloro-, 3-Chloro-6-cyanopyridine, 2-cyano-5-chloropyridine, 5-chloropicolinenitrile, 5-chloro-2-cyano pyridine, SCHEMBL69932, 5-chloro-pyridine-2-carbonitrile, WTHODOKFSYPTKA-UHFFFAOYSA-N, 5-chloranylpyridine-2-carbonitrile, BCP22240, BBL100618, RB1002, SBB055739, STL554412, AKOS005255050, AC-5432, CS-W019579, PS-3446, NCGC00664512-01, SY007565, DB-007004, C3023, EN300-100627, A843328

Application

5-Chloro-2-cyanopyridine serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral and antitumor agents. The compound’s reactive nitrile group enables conversion to amidines, tetrazoles, and carboxylic acid derivatives for drug discovery applications. In material science, it acts as a precursor for functionalized pyridine ligands in catalytic systems. The chlorine substituent facilitates further functionalization via metal-catalyzed cross-coupling reactions in medicinal chemistry workflows.

Safety and Hazards

GHS Hazard Statements

• H301+H311+H331 (33.3%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
• H301 (33.3%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (33.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (33.3%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (66.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H317 (33.3%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (33.3%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H332 (33.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (33.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P262, P264, P264+P265, P270, P271, P272, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P332+P317, P333+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (33.3%)
• Acute Tox. 3 (33.3%)
• Skin Irrit. 2 (66.7%)
• Skin Sens. 1 (33.3%)
• Eye Irrit. 2A (100%)
• Acute Tox. 3 (33.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.