Description

5-Chloro-1H-indole-3-ethylamine monohydrochloride (CAS: 942-26-7) is a high-purity, research-grade chemical compound with the molecular formula C₁₀H₁₂Cl₂N₂. This indole derivative is widely utilized in pharmaceutical research, neuroscience, and biochemical applications due to its structural similarity to tryptamine and serotonin-related compounds. The product is supplied as a white to off-white crystalline powder, ensuring optimal solubility in aqueous and organic solvents for experimental use. Each batch undergoes rigorous quality control (HPLC, NMR) to guarantee ≥98% purity, making it ideal for receptor binding studies, enzyme assays, and synthetic intermediates. Store at 2-8°C in a tightly sealed container under inert conditions to maintain stability.

Properties

• CAS Number: 942-26-7
• Complexity: 174
• IUPAC Name: 2-(5-chloro-1H-indol-3-yl)ethanamine;hydrochloride
• InChI: InChI=1S/C10H11ClN2.ClH/c11-8-1-2-10-9(5-8)7(3-4-12)6-13-10;/h1-2,5-6,13H,3-4,12H2;1H
• InChI Key: PBANXRNIXGEHPZ-UHFFFAOYSA-N
• Exact Mass: 230.0377538
• Molecular Formula: C10H12Cl2N2
• Molecular Weight: 231.12
• SMILES: C1=CC2=C(C=C1Cl)C(=CN2)CCN.Cl
• Topological: 41.8
• Monoisotopic Mass: 230.0377538
• Synonyms: EINECS 213-387-8, 5-Chloro-1H-indole-3-ethylamine monohydrochloride, 1H-Indole-3-ethanamine, 5-chloro-, hydrochloride (1:1), 213-387-8, 5-Chlorotryptamine Hydrochloride, 942-26-7, 2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride, 5-chlorotryptamine, hcl, 5-Chloro-1H-indole-3-ethylamine hydrochloride, 55747-73-4, MFCD00051990, 2-(5-chloro-1H-indol-3-yl)ethanamine;hydrochloride, 1H-Indole-3-ethanamine, 5-chloro-, monohydrochloride, 5-Chloro-1H-indole-3-ethylamine HCl, 2-(5-chloro-1H-indol-3-yl)ethan-1-amine hydrochloride, 5-Chlorotryptamine HCl, EINECS 259-789-7, BIM-0013443.P001, FD7RS43ALK, 5-Chloro-3-(2-aminoethyl)indole Hydrochloride, SCHEMBL686594, SCHEMBL892839, DTXSID60971121, AKOS001475939, FC52414, GS-3392, AC-23958, PD133591, SY021124, DB-013912, ST50407466, EN300-91838, 1H-Indole-3-ethanamine, 5-chloro-, hydrochloride, Indole, 3-(2-aminoethyl)-5-chloro-, hydrochloride, 2-(5-chloro-1H-indol-3-yl) ethanamine hydrochloride, [2-(5-chloro-1H-indol-3-yl)ethyl]amine hydrochloride, Z1266933935, 2-(5-Chloro-1H-indol-3-yl)ethan-1-amine–hydrogen chloride (1/1), 2-(5-Chloro-1H-indol-3-yl)ethylamine hydrochloride, AldrichCPR, 2-(5-Chloro-1H-indol-3-yl)ethanamine hydrochloride;5-Chloro-3-(2-aminoethyl)indole hydrochloride

5-Chloro-1H-indole-3-ethylamine monohydrochloride serves as a key intermediate in the synthesis of serotonin receptor ligands and psychoactive compounds. Researchers employ it in neuropharmacological studies to investigate serotoninergic pathways and receptor modulation. Its chlorinated indole core also facilitates the development of fluorescent probes for cellular imaging. Suitable for in vitro assays requiring precise agonist/antagonist characterization.

Safety and Hazards

GHS Hazard Statements

• H302 (11.1%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (88.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (88.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (77.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (11.1%)
• Skin Irrit. 2 (88.9%)
• Eye Irrit. 2 (88.9%)
• STOT SE 3 (77.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.