Description

Description

5-Bromo-4-fluoro-2-nitrobenzaldehyde (CAS No. 213382-45-7) is a high-purity aromatic aldehyde derivative with the molecular formula C₇H₃BrFNO₃. This compound features a benzaldehyde core substituted with bromo, fluoro, and nitro functional groups at the 5, 4, and 2 positions, respectively, making it a versatile intermediate for organic synthesis and pharmaceutical research. Its molecular weight of 248.01 g/mol and precise structural configuration ensure consistent reactivity in nucleophilic aromatic substitution (S_NAr) and cross-coupling reactions. Available in crystalline solid form with ??95% purity (HPLC), it is packaged under inert conditions to maintain stability. Ideal for use in Suzuki-Miyaura couplings, peptidomimetics, and agrochemical synthesis, this compound is supplied with comprehensive analytical data (NMR, MS, FTIR) for quality assurance.

Application

5-Bromo-4-fluoro-2-nitrobenzaldehyde serves as a key building block in medicinal chemistry for the synthesis of kinase inhibitors and antibacterial agents. Its electron-deficient aromatic ring facilitates palladium-catalyzed cross-coupling reactions to generate biaryl scaffolds. The compound is also employed in the development of fluorescent probes and nonlinear optical materials due to its nitro and aldehyde functional groups. Researchers utilize it in heterocyclic chemistry to construct indoles and quinolines via reductive cyclization.

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