Description

5-Bromo-2,4-difluoroaniline (CAS No. 452-92-6) is a high-purity halogenated aniline derivative with the molecular formula C₆H₄BrF₂N. This compound is characterized by its bromo and fluoro substituents on the aromatic ring, making it a versatile intermediate in organic synthesis and pharmaceutical research. Its IUPAC name is 5-bromo-2,4-difluoroaniline, and it is supplied as a crystalline solid with guaranteed purity suitable for laboratory and industrial applications. Ideal for researchers in medicinal chemistry, agrochemical development, and material science, this reagent is rigorously tested for consistency and stability. Store in a cool, dry place under inert conditions to maintain optimal quality.

Properties

• CAS Number: 452-92-6
• Complexity: 122
• IUPAC Name: 5-bromo-2,4-difluoro-aniline
• InChI: InChI=1S/C6H4BrF2N/c7-3-1-6(10)5(9)2-4(3)8/h1-2H,10H2
• InChI Key: FQZCUAASVCIWSL-UHFFFAOYSA-N
• Exact Mass: 206.94952
• Molecular Formula: C6H4BrF2N
• Molecular Weight: 208.00
• SMILES: C1=C(C(=CC(=C1Br)F)F)N
• Topological: 26
• Monoisotopic Mass: 206.94952
• Synonyms: 5-Bromo-2,4-difluoroaniline, 452-92-6, DTXSID30382563, DTXCID60333588, 627-420-2, 5-Bromo-2,4-difluoro-phenylamine, 5-bromo-2,4-difluoro-aniline, MFCD03426368, 5-bromo-2,4-difluorophenylamine, 2,4-Difluoro-5-bromoaniline, Benzenamine, 5-bromo-2,4-difluoro-, 5-bromo-2,4-difluoro aniline, SCHEMBL1529272, FQZCUAASVCIWSL-UHFFFAOYSA-N, SBB070450, 5-Bromo-2,4-difluoroaniline, 96%, AKOS015834017, AC-6668, CS-W015244, SB77807, AS-37130, SY060840, 5-Bromo-2 pound not4-difluoro-phenylamine, DB-051292, EN300-132490

Application

5-Bromo-2,4-difluoroaniline is widely used as a key building block in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. Its reactive amino and halogen groups facilitate cross-coupling reactions, such as Buchwald-Hartwig amination or Suzuki-Miyaura coupling, to construct complex aromatic frameworks. This compound is particularly valuable in the development of active pharmaceutical ingredients (APIs) and advanced materials requiring halogenated aniline motifs. Researchers also utilize it in the preparation of dyes, ligands, and catalysts due to its electron-withdrawing properties.

Safety and Hazards

GHS Hazard Statements

• H301 (97.5%): Toxic if swallowed [Danger Acute toxicity, oral]

Precautionary Statements

• P264, P270, P301+P316, P321, P330, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (97.5%)

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