Description

5-Bromo-2,3-Difluorophenol (CAS No. 186590-26-1) is a high-purity halogenated phenol derivative with the molecular formula C₆H₃BrF₂O. This specialized chemical compound is designed for advanced research and industrial applications, offering exceptional reactivity due to its bromo and difluoro substitutions on the phenolic ring. It is an essential intermediate in organic synthesis, particularly in pharmaceuticals, agrochemicals, and material science. Our product undergoes rigorous quality control to ensure ≥98% purity (HPLC/GC), with detailed analytical certificates provided. Available in scalable quantities from milligrams to kilograms, it is packaged under inert conditions to guarantee stability and longevity. Ideal for cross-coupling reactions, nucleophilic substitutions, and as a building block for complex fluorinated architectures.

Properties

• CAS Number: 186590-26-1
• Complexity: 122
• IUPAC Name: 5-bromo-2,3-difluoro-phenol
• InChI: InChI=1S/C6H3BrF2O/c7-3-1-4(8)6(9)5(10)2-3/h1-2,10H
• InChI Key: QAHCQGXGAYRHHW-UHFFFAOYSA-N
• Exact Mass: 207.93353
• Molecular Formula: C6H3BrF2O
• Molecular Weight: 208.99
• SMILES: C1=C(C=C(C(=C1O)F)F)Br
• Topological: 20.2
• Monoisotopic Mass: 207.93353
• Synonyms: 5-Bromo-2,3-difluorophenol, 186590-26-1, DTXSID00378357, DTXCID00329384, 606-090-3, 2,3-difluoro-5-bromophenol, MFCD01631350, Phenol, 5-bromo-2,3-difluoro-, 5-bromo-2,3-difluoro-phenol, SCHEMBL189947, 5-bromo-2,3-difluoro phenol, QAHCQGXGAYRHHW-UHFFFAOYSA-N, SBB094129, AKOS005064100, AC-1587, CS-W015186, DS-8555, SY022935, DB-025389, B4490, NS00124591, ST50826891, EN300-160000

5-Bromo-2,3-Difluorophenol is widely utilized as a key intermediate in the synthesis of fluorinated pharmaceuticals and bioactive molecules. Its reactive bromo and hydroxyl groups enable efficient participation in Suzuki-Miyaura and Buchwald-Hartwig couplings. Researchers employ it to develop novel agrochemicals, liquid crystals, and advanced polymers with tailored properties. The compound’s unique electronic effects from fluorine substitution make it valuable in medicinal chemistry for optimizing drug potency and metabolic stability.

Safety and Hazards

GHS Hazard Statements

• H302 (10.6%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (97.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (97.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (95.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (10.6%)
• Skin Irrit. 2 (97.9%)
• Eye Irrit. 2A (97.9%)
• STOT SE 3 (95.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.