Description

Description

5-Bromo-2,3-difluorobenzonitrile (CAS No. 1105665-42-6) is a high-purity halogenated aromatic compound with the molecular formula C₇H₂BrF₂N. This specialized chemical features a benzonitrile core functionalized with bromine and two fluorine atoms at the 5-, 2-, and 3-positions, respectively, offering unique electronic and steric properties for advanced synthetic applications. With a molecular weight of 218.00 g/mol, it is supplied as a crystalline solid with ??95% purity (HPLC) and is rigorously tested for consistency in moisture content, residual solvents, and heavy metals. Ideal for cross-coupling reactions, pharmaceutical intermediates, and material science research, this compound is packaged under inert gas in amber glass vials with optional argon-sealed ampoules for air-sensitive protocols. Technical data sheets include 1H/13C NMR, HPLC chromatograms, and FT-IR spectra for batch-to-batch verification.

Application

5-Bromo-2,3-difluorobenzonitrile serves as a versatile building block in Suzuki-Miyaura and Buchwald-Hartwig couplings for constructing polyfluorinated biaryl systems in drug discovery. Its electron-deficient aromatic ring enhances reactivity in nucleophilic aromatic substitutions (SNAr) for agrochemical and pharmaceutical intermediates. The compound is also employed in liquid crystal and OLED material synthesis, where the bromo-cyano motif facilitates ??-conjugation tuning.

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