Atomfair 5-Bromo-2-methoxypyridine-3-sulfonyl chloride C6H5BrClNO3S CAS 1261584-19-3

Description

5-Bromo-2-methoxypyridine-3-sulfonyl chloride (CAS No. 1261584-19-3) is a high-purity sulfonyl chloride derivative widely used in organic synthesis and pharmaceutical research. With the molecular formula C₆H₅BrClNO₃S, this compound serves as a versatile building block for the preparation of sulfonamides and other functionalized pyridine derivatives. Its reactive sulfonyl chloride group enables efficient coupling with amines, alcohols, and other nucleophiles, making it invaluable in medicinal chemistry and drug discovery.

This product is rigorously tested for quality, ensuring >95% purity by HPLC analysis. It is supplied as a crystalline solid under inert conditions to maintain stability. Suitable for use in combinatorial chemistry, high-throughput screening, and as an intermediate in the synthesis of biologically active molecules. Store in a cool, dry place away from moisture and incompatible reagents.

Properties

• CAS Number: 1261584-19-3
• Complexity: 266
• IUPAC Name: 5-bromo-2-methoxy-pyridine-3-sulfonyl chloride
• InChI: InChI=1S/C6H5BrClNO3S/c1-12-6-5(13(8,10)11)2-4(7)3-9-6/h2-3H,1H3
• InChI Key: HPGXYLFNEUZNHH-UHFFFAOYSA-N
• Exact Mass: 284.88620
• Molecular Formula: C6H5BrClNO3S
• Molecular Weight: 286.53
• SMILES: COC1=C(C=C(C=N1)Br)S(=O)(=O)Cl
• Topological: 64.6
• Monoisotopic Mass: 284.88620
• Synonyms: 5-bromo-2-methoxypyridine-3-sulfonyl chloride, 1261584-19-3, 830-162-5, 5-Bromo-2-methoxy-3-pyridinesulfonyl Chloride, C6H5BrClNO3S, SCHEMBL27103224, AKOS032952372, DB-398138, 5-bromo-2-methoxypyridine-3-sulfonylchloride, EN300-78503, 5-bromo-2-methoxy-pyridine-3-sulfonyl chloride, G75228

Application

5-Bromo-2-methoxypyridine-3-sulfonyl chloride is primarily employed as a key intermediate in the synthesis of sulfonamide-based pharmaceuticals and agrochemicals. Its reactive sulfonyl chloride moiety allows for efficient conjugation with amines to form sulfonamides, a common pharmacophore in drug design. Researchers utilize this compound in the development of kinase inhibitors and other small-molecule therapeutics targeting various disease pathways. It is also used in material science for modifying pyridine-containing polymers.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P260, P261, P264, P271, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P319, P321, P363, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (100%)
• STOT SE 3 (100%)

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