Description

5-Bromo-2-hydroxy-3-methylpyridine (CAS No. 89488-30-2) is a high-purity brominated pyridine derivative with the molecular formula C₆H₆BrNO. This compound is widely utilized in pharmaceutical research, agrochemical development, and organic synthesis due to its versatile reactivity as a halogenated heterocyclic building block. The presence of both bromo and hydroxyl functional groups on the pyridine ring enables selective modifications, making it valuable for cross-coupling reactions, metal-catalyzed transformations, and medicinal chemistry applications. Our product is rigorously tested to ensure ≥97% purity (HPLC/GC) and is supplied as a crystalline solid with excellent batch-to-batch consistency. Suitable for high-throughput screening (HTS) and combinatorial chemistry, it is packaged under inert gas to maintain stability. SDS and analytical certificates (CoA) are available upon request.

Properties

• CAS Number: 89488-30-2
• Complexity: 205
• IUPAC Name: 5-bromo-3-methyl-1H-pyridin-2-one
• InChI: InChI=1S/C6H6BrNO/c1-4-2-5(7)3-8-6(4)9/h2-3H,1H3,(H,8,9)
• InChI Key: HXPMRPRBABWPKL-UHFFFAOYSA-N
• Exact Mass: 186.96328
• Molecular Formula: C6H6BrNO
• Molecular Weight: 188.02
• SMILES: CC1=CC(=CNC1=O)Br
• Topological: 29.1
• Monoisotopic Mass: 186.96328
• Synonyms: 5-Bromo-2-hydroxy-3-methylpyridine, DTXSID70301314, DTXCID20252448, 624-831-9, 89488-30-2, 5-bromo-3-methylpyridin-2-ol, 5-Bromo-2-hydroxy-3-picoline, 5-Bromo-3-methylpyridin-2(1H)-one, 5-bromo-3-methyl-1H-pyridin-2-one, MFCD03427657, 5-bromo-2-hydroxy-3-methyl pyridine, 5-bromo-3-methyl-pyridin-2-ol, 5-Bromo-3-methyl-2-pyridinol, 2-hydroxy-3-methyl-5-bromopyridine, 2(1H)-PYRIDINONE, 5-BROMO-3-METHYL-, 5-Bromo-3-methyl-2-pyridone, NSC142314, 5-Bromo-2-hydroxy-3-picoline (5-Bromo-2-hydroxy-3-methylpyridine), 5-BROMO-3-METHYL-2-HYDROXYPYRIDINE, SCHEMBL590523, SCHEMBL650675, 2-Pyridinol, 5-bromo-3-methyl-, BCP22176, CS-D0817, SBB013903, STK783258, 5-bromo-3-methyl-2(1H)-pyridinone, AKOS001728766, AKOS022171435, AB15087, FS-2149, NSC 142314, NSC-142314, AC-23063, HY-75423, ST093945, SY007024, 5-Bromo-2-hydroxy-3-methylpyridine, 97%, DB-029082, B2797, EN300-102013, AE-018/31855039, Z1251353012

5-Bromo-2-hydroxy-3-methylpyridine serves as a key intermediate in synthesizing bioactive molecules, particularly in antiviral and anticancer drug discovery. Its bromo substituent facilitates Suzuki-Miyaura and Buchwald-Hartwig couplings for constructing complex heterocycles. Researchers employ it in ligand design for transition metal catalysts and as a precursor for functionalized pyridine scaffolds in material science. The compound’s stability under acidic conditions makes it suitable for multi-step synthetic routes in medicinal chemistry programs.

Safety and Hazards

GHS Hazard Statements

• H302 (97.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (93.2%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

Precautionary Statements

• P264, P264+P265, P270, P280, P301+P317, P302+P352, P305+P354+P338, P317, P321, P330, P332+P317, P362+P364, and P501

Hazard Classes and Categories

• Acute Tox. 4 (97.7%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (93.2%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.