Description

5-Bromo-2-fluoropyridine (CAS No. 766-11-0) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₃BrFN. This compound is a versatile building block in pharmaceutical, agrochemical, and materials science research, offering excellent reactivity for cross-coupling reactions, nucleophilic substitutions, and metal-catalyzed transformations. Its bromo and fluoro substituents enable selective functionalization, making it invaluable for synthesizing complex heterocyclic scaffolds. Available in >98% purity (GC), this product is rigorously tested for consistency and stability, packaged under inert gas to ensure longevity. Suitable for use in HPLC, NMR, and LC-MS applications, it is supplied in amber glass vials with traceable lot numbers for quality assurance.

Properties

• CAS Number: 766-11-0
• Complexity: 78.8
• IUPAC Name: 5-bromo-2-fluoro-pyridine
• InChI: InChI=1S/C5H3BrFN/c6-4-1-2-5(7)8-3-4/h1-3H
• InChI Key: MYUQKYGWKHTRPG-UHFFFAOYSA-N
• Exact Mass: 174.94329
• Molecular Formula: C5H3BrFN
• Molecular Weight: 175.99
• SMILES: C1=CC(=NC=C1Br)F
• Topological: 12.9
• Monoisotopic Mass: 174.94329
• Synonyms: 5-Bromo-2-fluoropyridine, 766-11-0, 2-Fluoro-5-bromopyridine, DTXSID40382478, DTXCID60333503, 629-380-1, 3-bromo-6-fluoropyridine, 5-bromo-2-fluoro-pyridine, MFCD01863742, Pyridine, 5-bromo-2-fluoro-, 5-Bromo-2-Fluoro Pyridine, 3-Bromo-6-fluoropyridine; 5-Bromo-2-fluoropyridine, 2-fluro-5-bromo-pyridine, SCHEMBL114154, SCHEMBL1761777, 5-Bromo-2-fluoropyridine, 99%, BCP22215, CS-D0938, SBB089108, AKOS005064074, AC-7427, CL-0780, PB30707, PS-8592, BP-21199, HY-32746, DB-005371, B2705, ST50408838, EN300-62001, F0001-3443, Z977035742

Application

5-Bromo-2-fluoropyridine is widely employed as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals. Its reactive halogen sites facilitate Suzuki-Miyaura and Buchwald-Hartwig couplings for drug discovery. Researchers also utilize it to develop fluorescent probes and ligands for catalysis. The compound’s stability under diverse reaction conditions makes it ideal for exploratory organic synthesis.

Safety and Hazards

GHS Hazard Statements

• H302 (11.5%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (98.1%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (98.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (17.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (96.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (11.5%)
• Skin Irrit. 2 (98.1%)
• Eye Irrit. 2 (98.1%)
• Acute Tox. 4 (17.3%)
• STOT SE 3 (96.2%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.