Description

5-Bromo-2-fluoropyridin-3-amine (CAS No. 884495-22-1) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₄BrFN₂. This compound is a valuable building block in pharmaceutical and agrochemical research, offering versatile reactivity due to its bromo and fluoro substituents on the pyridine ring. Its amine functionality further enhances its utility in coupling reactions, making it ideal for synthesizing complex heterocycles. Suitable for cross-coupling (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitution reactions. Packaged under inert conditions to ensure stability and provided with comprehensive analytical data (HPLC, NMR, MS) for quality assurance. Available in research quantities (mg to kg scale) with customizable packaging.

Properties

• CAS Number: 884495-22-1
• Complexity: 101
• IUPAC Name: 5-bromo-2-fluoro-pyridin-3-amine
• InChI: InChI=1S/C5H4BrFN2/c6-3-1-4(8)5(7)9-2-3/h1-2H,8H2
• InChI Key: CLYOMCMDBNNGSM-UHFFFAOYSA-N
• Exact Mass: 189.95419
• Molecular Formula: C5H4BrFN2
• Molecular Weight: 191.00
• SMILES: C1=C(C=NC(=C1N)F)Br
• Topological: 38.9
• Monoisotopic Mass: 189.95419
• Synonyms: 884495-22-1, 5-Bromo-2-fluoropyridin-3-amine, DTXSID40590293, DTXCID30541057, 687-293-4, 3-Amino-5-bromo-2-fluoropyridine, MFCD06659524, 5-bromo-2-fluoro-pyridin-3-amine, 2-fluoro-3-amino-5-bromopyridine, 5-bromo-2-fluoro-pyridin-3-ylamine, SCHEMBL858870, 5-bromo-2-fluoro-3-pyridylamine, CLYOMCMDBNNGSM-UHFFFAOYSA-N, BBL103881, SBB070323, STL557691, AKOS005255318, CS-W015859, PS-8362, 3-Amino-5-bromo-2-fluoropyridine, 97%, AC-24930, SY101419, DB-023139, EN300-133584

Application

5-Bromo-2-fluoropyridin-3-amine is widely used as a key intermediate in medicinal chemistry for the synthesis of biologically active molecules, including kinase inhibitors and antimicrobial agents. Its halogenated pyridine core facilitates the development of targeted drug candidates through selective functionalization. Researchers also employ it in material science for designing advanced ligands and functional polymers. The compound’s reactivity is leveraged in palladium-catalyzed cross-coupling reactions to construct complex aromatic systems.

Safety and Hazards

GHS Hazard Statements

• H302 (97.6%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (97.6%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.