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Atomfair 5-Bromo-2-fluorobenzonitrile C7H3BrFN

Description 5-Bromo-2-fluorobenzonitrile (CAS No. 179897-89-3) is a high-purity halogenated aromatic nitrile compound with the molecular formula C7H3BrFN . This fine chemical is an essential intermediate in organic synthesis, particularly in pharmaceutical and agrochemical research. Its unique structure, featuring both bromo and fluoro substituents on the benzonitrile scaffold, enables versatile reactivity in cross-coupling reactions, nucleophilic substitutions, and cyanation transformations. Supplied as a white to off-white crystalline solid with ??95% purity (HPLC), it is rigorously tested for consistency and stability. Ideal for medicinal chemistry, material science, and ligand design, this compound is packaged under inert gas to ensure longevity and stored in…

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Description

Description

5-Bromo-2-fluorobenzonitrile (CAS No. 179897-89-3) is a high-purity halogenated aromatic nitrile compound with the molecular formula C7H3BrFN. This fine chemical is an essential intermediate in organic synthesis, particularly in pharmaceutical and agrochemical research. Its unique structure, featuring both bromo and fluoro substituents on the benzonitrile scaffold, enables versatile reactivity in cross-coupling reactions, nucleophilic substitutions, and cyanation transformations. Supplied as a white to off-white crystalline solid with ??95% purity (HPLC), it is rigorously tested for consistency and stability. Ideal for medicinal chemistry, material science, and ligand design, this compound is packaged under inert gas to ensure longevity and stored in amber glass vials to prevent photodegradation. Available in research quantities (100mg to 10g) with optional certificates of analysis (CoA) upon request.

  • CAS No: 179897-89-3
  • Molecular Formula: C7H3BrFN
  • Molecular Weight: 200.01
  • Exact Mass: 198.94329
  • Monoisotopic Mass: 198.94329
  • IUPAC Name: 5-bromo-2-fluorobenzonitrile
  • SMILES: C1=CC(=C(C=C1Br)C#N)F
  • Synonyms: 5-Bromo-2-fluorobenzonitrile, 179897-89-3, DTXSID10369276, DTXCID60320312, 605-873-7

Application

5-Bromo-2-fluorobenzonitrile serves as a key building block in Suzuki-Miyaura and Buchwald-Hartwig couplings for drug discovery, particularly in kinase inhibitor development. Its electron-withdrawing cyano group enhances reactivity in palladium-catalyzed arylations, while the bromo/fluoro motifs enable selective functionalization. Researchers utilize this compound in the synthesis of fluorinated liquid crystals and OLED materials due to its stable aromatic core. It also finds use in agrochemical intermediates for crop protection agents.

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