Description

5-Bromo-2-(chloromethyl)-1,3-difluorobenzene (CAS No. 175589-02-3) is a high-purity halogenated aromatic compound with the molecular formula C₇H₄BrClF₂. This specialized chemical features a bromo-substituted benzene ring with both chloro- and difluoro-functional groups, making it a versatile intermediate for advanced organic synthesis. Its unique structure enables selective reactivity in cross-coupling reactions, nucleophilic substitutions, and pharmaceutical derivatization. Supplied as a crystalline solid or solution (upon request), each batch undergoes rigorous QC testing including GC/HPLC, NMR, and mass spectrometry to ensure ≥95% purity (custom purities available). Ideal for researchers developing fluorinated agrochemicals, liquid crystals, or PET radiotracers. Packaged under inert gas in amber glass to ensure stability. Available in research (1g-100g) and bulk (1kg+) quantities with optional COA/MSDS documentation.

Properties

• CAS Number: 175589-02-3
• Complexity: 122
• IUPAC Name: 5-bromo-2-(chloromethyl)-1,3-difluoro-benzene
• InChI: InChI=1S/C7H4BrClF2/c8-4-1-6(10)5(3-9)7(11)2-4/h1-2H,3H2
• InChI Key: MIRBGKHXWLNQOC-UHFFFAOYSA-N
• Exact Mass: 239.91530
• Molecular Formula: C7H4BrClF2
• Molecular Weight: 241.46
• SMILES: C1=C(C=C(C(=C1F)CCl)F)Br
• Monoisotopic Mass: 239.91530
• Synonyms: 175589-02-3, 4-Bromo-2,6-difluorobenzyl chloride, 5-Bromo-2-(chloromethyl)-1,3-difluorobenzene, 5-Bromo-2-(aminomethyl)-1,3-difluorobenzene, MFCD09029218, Benzene, 5-bromo-2-(chloromethyl)-1,3-difluoro-, SCHEMBL8729481, DTXSID50599393, AC8388, AKOS015961074, AC-12988, BS-21760, SY249560, EN300-330657

Application

This compound serves as a key building block for synthesizing fluorinated bioactive molecules, particularly in pharmaceutical R&D where its bromo- and chloromethyl groups enable sequential functionalization. Researchers utilize it to create novel difluorobenzyl scaffolds for kinase inhibitors and CNS-targeting drugs. The electron-withdrawing fluorine atoms enhance metabolic stability in candidate compounds. In materials science, it’s employed to modify polymer side chains for enhanced thermal resistance. Also finds use in palladium-catalyzed cross-couplings to construct complex aryl-aryl bonds.

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.