Description

5-Bromo-2-chloro-4-methyl-3-nitropyridine (CAS No. 884495-15-2) is a high-purity nitropyridine derivative with the molecular formula C₆H₄BrClN₂O₂. This halogenated heterocyclic compound is a versatile intermediate in organic synthesis, particularly in pharmaceutical and agrochemical research. Its unique structure, featuring bromo, chloro, methyl, and nitro functional groups on a pyridine backbone, enables selective reactivity for cross-coupling reactions, nucleophilic substitutions, and other transformations. Supplied as a crystalline solid with ≥95% purity (HPLC), it is ideal for medicinal chemistry, material science, and ligand development. Store under inert conditions at 2-8°C to ensure stability. Available in research quantities with full analytical documentation (NMR, MS, HPLC).

Properties

• CAS Number: 884495-15-2
• Complexity: 187
• IUPAC Name: 5-bromo-2-chloro-4-methyl-3-nitro-pyridine
• InChI: InChI=1S/C6H4BrClN2O2/c1-3-4(7)2-9-6(8)5(3)10(11)12/h2H,1H3
• InChI Key: BLJOCKNDWUTFEN-UHFFFAOYSA-N
• Exact Mass: 249.91447
• Molecular Formula: C6H4BrClN2O2
• Molecular Weight: 251.46
• SMILES: CC1=C(C(=NC=C1Br)Cl)[N+](=O)[O-]
• Topological: 58.7
• Monoisotopic Mass: 249.91447
• Synonyms: 5-BROMO-2-CHLORO-4-METHYL-3-NITROPYRIDINE, 884495-15-2, DTXSID20654564, DTXCID20605314, 815-599-1, 5-Bromo-2-chloro-3-nitro-4-picoline, MFCD06659505, SCHEMBL1366985, BLJOCKNDWUTFEN-UHFFFAOYSA-N, AKOS015833892, CS-W010207, GS-5044, SB52232, AC-24915, SY025768, EN300-247247

Application

5-Bromo-2-chloro-4-methyl-3-nitropyridine serves as a key building block in the synthesis of bioactive molecules, particularly in developing kinase inhibitors and antimicrobial agents. Its multifunctional pyridine core enables Suzuki-Miyaura and Buchwald-Hartwig couplings for drug discovery pipelines. The compound is also employed in material science for creating functionalized ligands in catalytic systems. Researchers utilize its nitro group for subsequent reduction to amino derivatives or heterocycle formation.

Safety and Hazards

GHS Hazard Statements

• H302 (66.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (66.7%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (66.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (66.7%)
• Acute Tox. 4 (66.7%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (66.7%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.