Description

5-Aminopyridine-2-carbonitrile (CAS No. 55338-73-3) is a high-purity organic compound with the molecular formula C₆H₅N₃. This heterocyclic building block features an amino group and a nitrile functionality on a pyridine scaffold, making it a versatile intermediate for pharmaceutical, agrochemical, and materials science research. With a molecular weight of 119.13 g/mol, it is supplied as a fine crystalline powder with ≥98% purity (HPLC). Ideal for nucleophilic substitution, cyclization, and cross-coupling reactions, this compound is rigorously tested for consistency and stored under nitrogen to ensure stability. Available in research quantities (100mg to 10kg) with optional custom packaging and COA/MSDS documentation.

Properties

• CAS Number: 55338-73-3
• Complexity: 134
• IUPAC Name: 5-aminopyridine-2-carbonitrile
• InChI: InChI=1S/C6H5N3/c7-3-6-2-1-5(8)4-9-6/h1-2,4H,8H2
• InChI Key: IFOXWHQFTSCNQB-UHFFFAOYSA-N
• Exact Mass: 119.048347172
• Molecular Formula: C6H5N3
• Molecular Weight: 119.12
• SMILES: C1=CC(=NC=C1N)C#N
• Topological: 62.7
• Monoisotopic Mass: 119.048347172
• Synonyms: 5-aminopyridine-2-carbonitrile, 677-663-3, 3-Amino-6-cyanopyridine, 55338-73-3, 5-aminopicolinonitrile, 5-Amino-2-cyanopyridine, 5-Amino-2-pyridinecarbonitrile, 5-Amino-2-cyano-pyridine, 2-cyano-5-aminopyridine, MFCD03093956, 2-Pyridinecarbonitrile, 5-amino-, 5-amino-2-cyano pyridine, SCHEMBL42349, SCHEMBL2643595, 5-amino-pyridine-2-carbonitrile, DTXSID30397657, IFOXWHQFTSCNQB-UHFFFAOYSA-N, BCP26820, SBB055614, 5-Amino-2-pyridinecarbonitrile, 96%, AKOS005137887, AC-6595, CS-W016585, PB14307, BP-10408, SY020835, TS-01610, DB-011401, EN300-66901, 5-Amino-2-cyanopyridine pound>>3-Amino-6-cyanopyridine, Z1065674734

Application

5-Aminopyridine-2-carbonitrile serves as a key precursor in the synthesis of fused heterocycles for drug discovery, particularly in kinase inhibitor development. Its reactive nitrile and amino groups enable facile derivatization for combinatorial chemistry libraries. Researchers also utilize it in metal-organic framework (MOF) design and as a ligand for catalytic systems. The compound’s pyridine core is valuable for constructing bioactive molecules with potential CNS activity.

Safety and Hazards

GHS Hazard Statements

• H301 (15.2%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (84.8%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (15.2%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H312 (84.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (87%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (84.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (84.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (15.2%)
• Acute Tox. 4 (84.8%)
• Acute Tox. 3 (15.2%)
• Acute Tox. 4 (84.8%)
• Skin Irrit. 2 (87%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (84.8%)
• STOT SE 3 (84.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.