Description

5-Amino-3-bromo-2-methoxypyridine (CAS No. 53242-18-5) is a high-purity heterocyclic compound with the molecular formula C₆H₇BrN₂O. This specialized chemical, also known by its IUPAC name 5-bromo-6-methoxypyridin-3-amine, is a valuable intermediate in pharmaceutical and agrochemical synthesis. The compound features a pyridine core substituted with amino, bromo, and methoxy functional groups, offering versatile reactivity for cross-coupling reactions, nucleophilic substitutions, and other transformations. Our product is rigorously tested to ensure >98% purity (HPLC) and is supplied as a fine crystalline powder with excellent batch-to-batch consistency. Suitable for research and development applications, this building block is particularly useful in medicinal chemistry for the preparation of biologically active molecules. Available in quantities from grams to kilograms, with custom packaging options upon request.

Properties

• CAS Number: 53242-18-5
• Complexity: 112
• IUPAC Name: 5-bromo-6-methoxy-pyridin-3-amine
• InChI: InChI=1S/C6H7BrN2O/c1-10-6-5(7)2-4(8)3-9-6/h2-3H,8H2,1H3
• InChI Key: YWYVVGOHQBANQI-UHFFFAOYSA-N
• Exact Mass: 201.97418
• Molecular Formula: C6H7BrN2O
• Molecular Weight: 203.04
• SMILES: COC1=C(C=C(C=N1)N)Br
• Topological: 48.1
• Monoisotopic Mass: 201.97418
• Synonyms: 5-Amino-3-bromo-2-methoxypyridine, 674-943-7, 53242-18-5, 5-bromo-6-methoxypyridin-3-amine, MFCD06659518, EN300-1294657, 5-bromo-6-methoxy-pyridin-3-amine, 5-bromo-6-methoxy-3-pyridylamine, 5-bromo-6-methoxy-pyridin-3-ylamine, 5-AMINO-3-BROMO-2-METHOXY-PYRIDIN, SCHEMBL1558307, DTXSID30612195, YWYVVGOHQBANQI-UHFFFAOYSA-N, BDBM626009, BCP22221, SBB070410, AKOS005258391, CS-W005236, FS-2161, PB48309, AC-27525, SY022514

Application

5-Amino-3-bromo-2-methoxypyridine serves as a key synthetic intermediate in pharmaceutical research, particularly for developing kinase inhibitors and other small molecule therapeutics. The compound’s bromo and amino groups make it valuable for palladium-catalyzed cross-coupling reactions in drug discovery programs. Researchers utilize this building block in the synthesis of complex heterocycles for potential agrochemical applications. Its unique substitution pattern also enables its use in materials science for creating functionalized pyridine derivatives.

Safety and Hazards

GHS Hazard Statements

• H302 (75%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (75%): Causes skin irritation [Warning Skin corrosion/irritation]
• H317 (75%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H318 (50%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (75%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (75%)
• Skin Irrit. 2 (75%)
• Skin Sens. 1 (75%)
• Eye Dam. 1 (50%)
• Eye Irrit. 2A (50%)
• STOT SE 3 (75%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.