Description

5-Amino-2-methyl-2,3-dihydro-1H-isoindole-1,3-dione (CAS No. 2307-00-8) is a high-purity organic compound with the molecular formula C₉H₈N₂O₂. This specialized chemical features an isoindole-1,3-dione core structure substituted with an amino group at the 5-position and a methyl group at the 2-position, making it a valuable intermediate for pharmaceutical and materials science research. Available in >97% purity (HPLC), it is supplied as a crystalline powder with excellent batch-to-batch consistency. The compound demonstrates good solubility in polar organic solvents such as DMSO and DMF while being sparingly soluble in water. Proper storage at 2-8°C under inert atmosphere ensures long-term stability. This product is ideal for researchers developing novel heterocyclic compounds, fluorescent probes, or bioactive molecules targeting neurological pathways.

Properties

• CAS Number: 2307-00-8
• Complexity: 264
• IUPAC Name: 5-amino-2-methyl-isoindoline-1,3-dione
• InChI: InChI=1S/C9H8N2O2/c1-11-8(12)6-3-2-5(10)4-7(6)9(11)13/h2-4H,10H2,1H3
• InChI Key: KMEBUNSLFRQSEM-UHFFFAOYSA-N
• Exact Mass: 176.058577502
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.17
• SMILES: CN1C(=O)C2=C(C1=O)C=C(C=C2)N
• Topological: 63.4
• Monoisotopic Mass: 176.058577502
• Synonyms: 5-amino-2-methyl-2,3-dihydro-1H-isoindole-1,3-dione, 622-563-7, 4-Amino-N-methylphthalimide, 2307-00-8, 5-Amino-2-methylisoindoline-1,3-dione, 5-amino-2-methylisoindole-1,3-dione, 1H-Isoindole-1,3(2H)-dione, 5-amino-2-methyl-, 5-amino-2-methyl-isoindole-1,3-dione, 5-amino-2-methyl-1H-isoindole-1,3(2H)-dione, MFCD00012081, EN300-02523, F1386-0358, N-Methyl-4-aminophthalimide, 4-Amino-N-methyl-phthalimid, Oprea1_420392, SCHEMBL917833, SCHEMBL2901880, DTXSID20352452, BDBM625946, HMS1789H16, SMSSF-0532336, 4-Amino-N-methylphthalimide, 97%, ALBB-022233, CAA30700, CCG-54996, SBB040049, STK057401, AKOS000111092, SB66132, 5-amino-2-methyl-1,3-isoindolinedione, AC-24980, AS-17371, SY036429, ST4125191, 5-amino-2-methylbenzo[c]azoline-1,3-dione, A1561, CS-0076926, 5-amino-2-methylbenzo[c]azolidine-1,3-dione, D82239, 1H-Isoindole-1,3(2H)-dione,4-amino-2-methyl-, SR-01000644050-1, Z57036341

This amino-substituted phthalimide derivative serves as a key building block in medicinal chemistry for the synthesis of CNS-active compounds. Researchers utilize it as a fluorescent tag in biochemical assays due to its stable emission properties. The compound has shown promise in developing inhibitors for protein-protein interactions in neurodegenerative disease models. Its rigid bicyclic structure makes it valuable for creating molecular probes with defined spatial geometry.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.6%)

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