Description

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinamine (CAS: 107335-49-9) is a high-purity boronic ester derivative designed for advanced research and pharmaceutical applications. This compound, with the molecular formula C₁₁H₁₇BN₂O₂, features a pyridinamine core functionalized with a pinacol boronate group, making it a versatile building block for Suzuki-Miyaura cross-coupling reactions. Its stability under ambient conditions and compatibility with organic solvents ensure ease of handling in synthetic workflows. Ideal for medicinal chemistry, material science, and agrochemical research, this reagent is rigorously tested for purity (typically >95%) and supplied with comprehensive analytical data (NMR, HPLC, MS). Store under inert conditions at 2-8°C to maintain optimal stability.

Properties

• CAS Number: 107335-49-9
• Complexity: 255
• IUPAC Name: 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine
• InChI: InChI=1S/C11H17BN2O2/c1-10(2)11(3,4)16-12(15-10)8-5-9(13)7-14-6-8/h5-7H,13H2,1-4H3
• InChI Key: DAISWHFZWZZBBD-UHFFFAOYSA-N
• Exact Mass: 220.1383080
• Molecular Formula: C11H17BN2O2
• Molecular Weight: 220.08
• SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CC(=CN=C2)N
• Topological: 57.4
• Monoisotopic Mass: 220.1383080
• Synonyms: 1073354-99-0, 3-AMINOPYRIDINE-5-BORONIC ACID, PINACOL ESTER, 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3-PYRIDINAMINE, DTXSID201178391, DTXCID601609744, 686-736-9, 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine, 107335-49-9, 3-Aminopyridine-5-boronic acid pinacol ester, 5-Aminopyridine-3-boronic acid, pinacol ester, 5-Aminopyridine-3-boronic acid pinacol ester, MFCD09260489, 5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan- 2-yl)-pyridin-3-ylamine, DAISWHFZWZZBBD-UHFFFAOYSA-N, SCHEMBL791063, (5-AMINOPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER, YSB35499, BBL101400, RB2037, SBB095884, STL555196, AKOS005258091, AB49991, CS-W006007, 5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDIN-3-YLAMINE, DS-13349, SY007607, DB-059626, 3-Aminopyridine-5-boronic acid pinacol ester, AldrichCPR, 4,4,5,5-tetramethyl-2-(5-amino-3-pyridyl)-1,3,2-dioxaborolane, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-aMinopyridine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridylamine

This compound is widely used as a key intermediate in the synthesis of bioactive molecules, particularly in the development of kinase inhibitors and other pharmaceutical agents. Its boronic ester moiety enables efficient cross-coupling reactions to construct complex heterocyclic scaffolds. Researchers also employ it in metal-organic framework (MOF) synthesis and as a ligand in catalytic systems. Suitable for both small-scale discovery and large-scale production.

Safety and Hazards

GHS Hazard Statements

• H301 (25%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (25%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (75%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (75%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (50%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (75%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (25%)
• Acute Tox. 4 (50%)
• Acute Tox. 4 (25%)
• Skin Irrit. 2 (75%)
• Eye Irrit. 2A (75%)
• Acute Tox. 4 (50%)
• STOT SE 3 (75%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.