Description

4,6-Dichloro-2-(propylthio)pyrimidin-5-amine (CAS No. 145783-15-9) is a high-purity pyrimidine derivative with the molecular formula C₇H₉Cl₂N₃S. This compound is a versatile intermediate in organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and specialty chemicals. Its IUPAC name, 4,6-dichloro-2-propylsulfanylpyrimidin-5-amine, reflects its precise chemical structure, featuring dichloro and propylthio substituents on a pyrimidine backbone.

This product is supplied as a fine crystalline powder with a purity of ≥95% (HPLC), ensuring reliable performance in research and industrial applications. It is soluble in common organic solvents such as DMSO, methanol, and dichloromethane, facilitating easy handling in synthetic protocols. Store in a cool, dry place under inert conditions to maintain stability.

Synonyms include: 4,6-dichloro-2-propylthiopyrimidine-5-amine, 808-051-8, and 4,6-DICHLORO-2-(PROPYLSULFANYL)PYRIMIDIN-5-AMINE.

Properties

• CAS Number: 145783-15-9
• Complexity: 149
• IUPAC Name: 4,6-dichloro-2-propylsulfanyl-pyrimidin-5-amine
• InChI: InChI=1S/C7H9Cl2N3S/c1-2-3-13-7-11-5(8)4(10)6(9)12-7/h2-3,10H2,1H3
• InChI Key: CJJLJBFJNXMANZ-UHFFFAOYSA-N
• Exact Mass: 236.9894239
• Molecular Formula: C7H9Cl2N3S
• Molecular Weight: 238.14
• SMILES: CCCSC1=NC(=C(C(=N1)Cl)N)Cl
• Topological: 77.1
• Monoisotopic Mass: 236.9894239
• Synonyms: 4,6-dichloro-2-(propylthio)pyrimidin-5-amine, 808-051-8, 145783-15-9, 4,6-dichloro-2-propylthiopyrimidine-5-amine, 4,6-DICHLORO-2-(PROPYLSULFANYL)PYRIMIDIN-5-AMINE, 5-Amino-4,6-dichloro-2-(propylthio)pyrimidine, 5-PYRIMIDINAMINE, 4,6-DICHLORO-2-(PROPYLTHIO)-, 4,6-dichloro-2-propylsulfanylpyrimidin-5-amine, MFCD16875503, QY0S1U6LEG, 4,6-Dichloro-2-(propylthio) pyrimidine-5-amine, 4,6-dichloro-2-(propylsulfanyl)-5-pyrimidinamine, 4,6-Dichloro-2-(propylthio)-5-pyrimidinamine; 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine; 5-Amino-4,6-dichloro-2-(propylthio)pyrimidine, UNII-QY0S1U6LEG, SCHEMBL595428, DTXSID60465838, CJJLJBFJNXMANZ-UHFFFAOYSA-N, BCP20990, CS-M1848, AKOS015851287, EX-7178, GS-5899, PB24255, AC-26815, BP-20662, SY023636, DB-063627, 5-amino-4,6-dichloro-2-propylthiopyrimidine, A2716, 4,6-Dichloro-2-propylthio-pyrimidine-5-amine, EN300-2953109, 4,6-Dichloro-2-propylthiopyrimidine-5-amine, AldrichCPR, Ticagrelor, Ticagrelor Intermediates, CAS:145783-15-9, 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine

Application

4,6-Dichloro-2-(propylthio)pyrimidin-5-amine is a key building block in the synthesis of heterocyclic compounds, particularly in medicinal chemistry for the development of kinase inhibitors and antimicrobial agents. Its reactive sites enable further functionalization, making it valuable for constructing complex molecular architectures. Researchers also utilize it in agrochemical research to develop novel pesticides and herbicides.

Safety and Hazards

GHS Hazard Statements

• H302 (40%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (20%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (20%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H413 (40%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P264, P264+P265, P270, P273, P280, P301+P317, P302+P352, P305+P351+P338, P321, P330, P332+P317, P337+P317, P362+P364, and P501

Hazard Classes and Categories

• Acute Tox. 4 (40%)
• Skin Irrit. 2 (20%)
• Eye Irrit. 2 (20%)
• Aquatic Chronic 4 (40%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.