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Atomfair 4,4,5,5-Tetramethyl-2-(thiophen-3-yl)-1,3,2-dioxaborolane C10H15BO2S CAS 214360-70-0

4,4,5,5-Tetramethyl-2-(thiophen-3-yl)-1,3,2-dioxaborolane (CAS No. 214360-70-0) is a high-purity boronic ester derivative with the molecular formula C10H15BO2S . This compound features a thiophene moiety coupled to a dioxaborolane ring, making it a valuable intermediate in organic synthesis and cross-coupling reactions. Its rigid, sterically hindered structure enhances stability, ensuring reliable performance in Suzuki-Miyaura and other palladium-catalyzed transformations. Ideal for researchers in pharmaceuticals, agrochemicals, and materials science, this reagent is supplied as a crystalline solid with ≥95% purity (GC). Store under inert conditions to maintain reactivity and shelf life. Available in scalable quantities with comprehensive analytical data (NMR, HPLC, MS) for quality assurance.

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Description

4,4,5,5-Tetramethyl-2-(thiophen-3-yl)-1,3,2-dioxaborolane (CAS No. 214360-70-0) is a high-purity boronic ester derivative with the molecular formula C10H15BO2S. This compound features a thiophene moiety coupled to a dioxaborolane ring, making it a valuable intermediate in organic synthesis and cross-coupling reactions. Its rigid, sterically hindered structure enhances stability, ensuring reliable performance in Suzuki-Miyaura and other palladium-catalyzed transformations. Ideal for researchers in pharmaceuticals, agrochemicals, and materials science, this reagent is supplied as a crystalline solid with ≥95% purity (GC). Store under inert conditions to maintain reactivity and shelf life. Available in scalable quantities with comprehensive analytical data (NMR, HPLC, MS) for quality assurance.

Properties

  • CAS Number: 214360-70-0
  • Complexity: 214
  • IUPAC Name: 4,4,5,5-tetramethyl-2-(3-thienyl)-1,3,2-dioxaborolane
  • InChI: InChI=1S/C10H15BO2S/c1-9(2)10(3,4)13-11(12-9)8-5-6-14-7-8/h5-7H,1-4H3
  • InChI Key: HQXQOBAEDQBINI-UHFFFAOYSA-N
  • Exact Mass: 210.0885811
  • Molecular Formula: C10H15BO2S
  • Molecular Weight: 210.11
  • SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CSC=C2
  • Topological: 46.7
  • Monoisotopic Mass: 210.0885811
  • Synonyms: 214360-70-0, 4,4,5,5-tetramethyl-2-(thiophen-3-yl)-1,3,2-dioxaborolane, DTXSID10375251, DTXCID30326280, 674-923-8, thiophene-3-boronic acid pinacol ester, 4,4,5,5-Tetramethyl-2-(3-thienyl)-1,3,2-dioxaborolane, thiophene-3-boronic acid, pinacol ester, 4,4,5,5-tetramethyl-2-thiophen-3-yl-1,3,2-dioxaborolane, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene, 1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl-2-(3-thienyl)-, MFCD05663893, 3-Thiopheneboronic acid pinacol ester, 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-thiophene, SCHEMBL1033417, HQXQOBAEDQBINI-UHFFFAOYSA-N, AKOS015950768, AB22039, AS-2654, SY122156, DB-010617, CS-0043239, EN300-262828, THIOPHEN-3-YLBORONIC ACID PINACOL ESTER, Z1269204423, 4,4,5,5-tetramethyl-2-thiophen-3-yl-[1,3,2]dioxaborolane

Application

4,4,5,5-Tetramethyl-2-(thiophen-3-yl)-1,3,2-dioxaborolane is widely used as a key building block in Suzuki-Miyaura cross-coupling reactions to synthesize biaryl compounds for drug discovery. Its thiophene-boronate structure facilitates the introduction of sulfur-containing heterocycles into complex molecules, enhancing electronic properties in organic semiconductors. This reagent is also employed in the development of conjugated polymers and advanced materials for optoelectronic applications.

Safety and Hazards

GHS Hazard Statements

  • H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
  • H315 (66.7%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (66.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
  • H335 (66.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (100%)
  • Acute Tox. 4 (100%)
  • Skin Irrit. 2 (66.7%)
  • Eye Irrit. 2A (66.7%)
  • Acute Tox. 4 (100%)
  • STOT SE 3 (66.7%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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