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Atomfair 4,4,5,5-Tetramethyl-2-(2-methylpropyl)-1,3,2-dioxaborolane C10H21BO2 CAS 67562-20-3

4,4,5,5-Tetramethyl-2-(2-methylpropyl)-1,3,2-dioxaborolane (CAS No. 67562-20-3) is a high-purity organoboron compound with the molecular formula C10H21BO2. This specialized boronic ester is widely utilized in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions, due to its stability and reactivity. The compound features a dioxaborolane ring with tetramethyl substitution, enhancing its steric and electronic properties for selective transformations. It is supplied as a clear, colorless to pale yellow liquid under inert conditions to ensure optimal shelf life and performance. Ideal for researchers in pharmaceuticals, materials science, and catalysis, this reagent is rigorously tested for purity (typically ≥95% by GC/NMR) and is available in various packaging…

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Description

4,4,5,5-Tetramethyl-2-(2-methylpropyl)-1,3,2-dioxaborolane (CAS No. 67562-20-3) is a high-purity organoboron compound with the molecular formula C10H21BO2. This specialized boronic ester is widely utilized in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions, due to its stability and reactivity. The compound features a dioxaborolane ring with tetramethyl substitution, enhancing its steric and electronic properties for selective transformations. It is supplied as a clear, colorless to pale yellow liquid under inert conditions to ensure optimal shelf life and performance. Ideal for researchers in pharmaceuticals, materials science, and catalysis, this reagent is rigorously tested for purity (typically ≥95% by GC/NMR) and is available in various packaging options to suit laboratory-scale or bulk requirements.

Properties

  • CAS Number: 67562-20-3
  • Complexity: 171
  • IUPAC Name: 2-isobutyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • InChI: InChI=1S/C10H21BO2/c1-8(2)7-11-12-9(3,4)10(5,6)13-11/h8H,7H2,1-6H3
  • InChI Key: FHQMPOBQBLDZJE-UHFFFAOYSA-N
  • Exact Mass: 184.1634601
  • Molecular Formula: C10H21BO2
  • Molecular Weight: 184.09
  • SMILES: B1(OC(C(O1)(C)C)(C)C)CC(C)C
  • Topological: 18.5
  • Monoisotopic Mass: 184.1634601
  • Synonyms: 67562-20-3, 4,4,5,5-tetramethyl-2-(2-methylpropyl)-1,3,2-dioxaborolane, DTXSID50542086, DTXCID70492872, 972-914-6, 2-Isobutyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, Isobutylboronic acid pinacol ester, MFCD17015837, 1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl-2-(2-methylpropyl)-, SCHEMBL10941261, FHQMPOBQBLDZJE-UHFFFAOYSA-N, Isobutylboronic acid, pinacol ester, AC8015, AKOS006335379, AS-3112, SY223896, DB-370611, CS-0154257, EN300-1706214

Application

4,4,5,5-Tetramethyl-2-(2-methylpropyl)-1,3,2-dioxaborolane is a key intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds in complex organic molecules. It is particularly valuable in pharmaceutical research for constructing biaryl scaffolds prevalent in drug candidates. The compound’s steric hindrance improves selectivity in coupling reactions with aryl halides or triflates. Additionally, it serves as a precursor in polymer chemistry and advanced material synthesis.

Safety and Hazards

GHS Hazard Statements

  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2A (100%)
  • STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

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  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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