Description

4,4-Difluoropiperidine hydrochloride (CAS No. 144230-52-4) is a high-purity organic compound with the molecular formula C₅H₁₀ClF₂N. This white to off-white crystalline powder is a valuable building block in pharmaceutical and agrochemical research, offering exceptional reactivity due to its difluorinated piperidine scaffold. With a molecular weight of 157.59 g/mol, this hydrochloride salt exhibits excellent solubility in polar solvents, making it ideal for nucleophilic substitution reactions and heterocyclic synthesis. Our product is rigorously tested to ensure ≥95% purity (HPLC) and is supplied in sealed, light-resistant containers under inert atmosphere to guarantee stability. Researchers will appreciate the batch-specific Certificate of Analysis, which includes detailed characterization by ¹H NMR, ¹³C NMR, and mass spectrometry. Suitable for medicinal chemistry applications, this compound is particularly useful for creating bioisosteres and modulating the physicochemical properties of lead compounds.

Properties

• CAS Number: 144230-52-4
• Complexity: 74.5
• IUPAC Name: 4,4-difluoropiperidine;hydrochloride
• InChI: InChI=1S/C5H9F2N.ClH/c6-5(7)1-3-8-4-2-5;/h8H,1-4H2;1H
• InChI Key: OABUKBBBSMNNPM-UHFFFAOYSA-N
• Exact Mass: 157.0469833
• Molecular Formula: C5H10ClF2N
• Molecular Weight: 157.59
• SMILES: C1CNCCC1(F)F.Cl
• Topological: 12
• Monoisotopic Mass: 157.0469833
• Synonyms: 4,4-Difluoropiperidine hydrochloride, 144230-52-4, DTXSID20374290, DTXCID00325321, 604-401-7, 4,4-DIFLUOROPIPERIDINE HCL, 4,4-difluoropiperidine;hydrochloride, MFCD03095381, piperidine, 4,4-difluoro-, hydrochloride (1:1), 4,4-Difluoropiperidine, HCl, 4,4-Difluoropiperidine (hydrochloride), 4,4-difluoropiperidine, chloride, 4,4-Difluoropiperidinehydrochloride, Piperidine, 4,4-difluoro-, hydrochloride, 4,4-Difluoropiperidine Hydrochloric acid, 4,4-difluoropiperidin HCl, 4,4-difluoropiperidine-hcl, SCHEMBL16582, difluoropiperidine hydrochloride, 4,4-difluoropiperidine HCl salt, 4,4-difluoropiperidine-HCl salt, 4,4-difluoropiperidin hydrochloride, SBB087231, 4,4 di-fluoropiperidine hydrochloride, 4,4-difluoro-piperidine hydrochloride, 4,4-difluoro-piperidine-hydrochloride, 4,4-difluoropiperidin-1-ium chloride, AKOS005063364, 4,4-difluoro-piperidine, hydrochloride, CS-W001440, HY-W001440, PB29234, PS-8824, SB10014, 4,4-difluoropiperidine monohydrochloride, AC-27441, SY011558, 4,4-Difluoro-piperidine hydrochloride salt, 4,4-Difluoropiperidine hydrochloride, 97%, DB-001280, 4 pound not4-Difluoropiperidine hydrochloride, EN300-194082, F0001-0513, Z1741959990

Application

4,4-Difluoropiperidine hydrochloride serves as a versatile intermediate in pharmaceutical research, particularly in the development of kinase inhibitors and GPCR-targeting therapeutics. The difluorinated piperidine moiety enhances metabolic stability and membrane permeability in drug candidates. This compound is frequently employed in structure-activity relationship (SAR) studies to investigate the impact of fluorination on pharmacokinetic properties. It’s also valuable for creating fluorinated analogs of bioactive piperidine derivatives in CNS drug discovery.

Safety and Hazards

GHS Hazard Statements

• H315 (20.4%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (18.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (20.4%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (18.4%)

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