Atomfair 4,4-Difluoro-L-prolinamide hydrochloride C5H9ClF2N2O CAS 426844-51-1

Description

4,4-Difluoro-L-prolinamide hydrochloride (CAS: 426844-51-1) is a high-purity fluorinated proline derivative designed for advanced research and pharmaceutical applications. With the molecular formula C₅H₉ClF₂N₂O, this compound serves as a critical chiral building block in organic synthesis, medicinal chemistry, and peptide modification. Its unique difluorinated pyrrolidine backbone enhances metabolic stability and bioavailability, making it invaluable for drug discovery and development. This product is rigorously tested for purity (>97%) and consistency, ensuring optimal performance in stereoselective reactions, enzyme inhibition studies, and proteomics research. Available in sealed, light-resistant packaging to maintain stability under recommended storage conditions.

Properties

• CAS Number: 426844-51-1
• Complexity: 160
• IUPAC Name: (2S)-4,4-difluoropyrrolidine-2-carboxamide;hydrochloride
• InChI: InChI=1S/C5H8F2N2O.ClH/c6-5(7)1-3(4(8)10)9-2-5;/h3,9H,1-2H2,(H2,8,10);1H/t3-;/m0./s1
• InChI Key: RRQDQYAEZGKHOB-DFWYDOINSA-N
• Exact Mass: 186.0371469
• Molecular Formula: C5H9ClF2N2O
• Molecular Weight: 186.59
• SMILES: C1[C@H](NCC1(F)F)C(=O)N.Cl
• Topological: 55.1
• Monoisotopic Mass: 186.0371469
• Synonyms: 4,4-Difluoro-L-prolinamide hydrochloride, 2-Pyrrolidinecarboxamide, 4,4-difluoro-, hydrochloride (1:1), (2S)-, 670-268-7, 426844-51-1, (S)-4,4-Difluoropyrrolidine-2-carboxamide hydrochloride, 4,4-DIFLUORO-L-PROLINAMIDE, HCL, (2S)-4,4-difluoropyrrolidine-2-carboxamide;hydrochloride, (2s)-4,4-difluoro-2-pyrrolidinecarboxamide hydrochloride, MFCD06797014, 4,4-Difluoro-l-prolinamide HCl, (2S)-2-Aminocarbonyl-4,4-difluoropyrrolidine Hydrochloride; (2S)-4,4-Difluoro-2-pyrrolidinecarboxamide Hydrochloride; (S)-4,4-Difluoropyrrolidine-2-carboxamide Hydrochloride;, C5H9ClF2N2O, SCHEMBL1347345, (S)-4,4-Difluoropyrolidine-2-carboxamide hydrochloride, DTXSID70669800, (2S)-4,4-DIFLUOROPYRROLIDINE-2-CARBOXAMIDE HYDROCHLORIDE, AKOS016844203, DS-5060, AC-33230, DB-388810, CS-0042848, 4,4-Difluoro-L-prolinamide hydrochloride, 97%, EN300-7390363, 4,4-Difluoro-L-prolinamide–hydrogen chloride (1/1), 2-Pyrrolidinecarboxamide,4,4-difluoro-,hydrochloride(1:1),(2S)-

4,4-Difluoro-L-prolinamide hydrochloride is widely used as a fluorinated proline analog in peptide synthesis to modulate conformational stability and biological activity. It serves as a key intermediate in the development of protease inhibitors and GPCR-targeting therapeutics. Researchers also employ it in structural biology to investigate fluorine-induced steric and electronic effects on protein-ligand interactions. Its applications extend to asymmetric catalysis and the design of novel bioactive molecules.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.