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Atomfair 4-(Trifluoromethylthio)phenyl triflate C8H4F6O3S2

Description 4-(Trifluoromethylthio)phenyl triflate (CAS: 1199773-43-7) is a high-purity organosulfur compound with the molecular formula C8H4F6O3S2, widely utilized in advanced organic synthesis and pharmaceutical research. This reagent features a trifluoromethylthio ( SCF3) group and a trifluoromethanesulfonate ( OTf ) moiety, making it a versatile building block for introducing trifluoromethylthio substituents or acting as a reactive intermediate in cross-coupling reactions. Its IUPAC name, [4-(trifluoromethylsulfanyl)phenyl] trifluoromethanesulfonate , reflects its precise chemical structure. Ideal for nucleophilic aromatic substitutions and catalytic transformations, this compound is rigorously tested for consistency and supplied in sealed packaging to ensure stability under inert conditions. Suitable for use in drug…

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Description

Description

4-(Trifluoromethylthio)phenyl triflate (CAS: 1199773-43-7) is a high-purity organosulfur compound with the molecular formula C8H4F6O3S2, widely utilized in advanced organic synthesis and pharmaceutical research. This reagent features a trifluoromethylthio (SCF3) group and a trifluoromethanesulfonate (OTf) moiety, making it a versatile building block for introducing trifluoromethylthio substituents or acting as a reactive intermediate in cross-coupling reactions. Its IUPAC name, [4-(trifluoromethylsulfanyl)phenyl] trifluoromethanesulfonate, reflects its precise chemical structure. Ideal for nucleophilic aromatic substitutions and catalytic transformations, this compound is rigorously tested for consistency and supplied in sealed packaging to ensure stability under inert conditions. Suitable for use in drug discovery, agrochemical development, and materials science.

  • CAS No: 1199773-43-7
  • Molecular Formula: C8H4F6O3S2
  • Molecular Weight: 326.2
  • Exact Mass: 325.95060530
  • Monoisotopic Mass: 325.95060530
  • IUPAC Name: [4-(trifluoromethylsulfanyl)phenyl] trifluoromethanesulfonate
  • SMILES: C1=CC(=CC=C1OS(=O)(=O)C(F)(F)F)SC(F)(F)F
  • Synonyms: 1199773-43-7, 4-(Trifluoromethylthio)phenyl triflate, 4-((Trifluoromethyl)thio)phenyl trifluoromethanesulfonate, Methanesulfonic acid, 1,1,1-trifluoro-, 4-[(trifluoromethyl)thio]phenyl ester, [4-(trifluoromethylsulfanyl)phenyl] trifluoromethanesulfonate

Application

4-(Trifluoromethylthio)phenyl triflate serves as a key electrophile in palladium-catalyzed cross-coupling reactions, enabling the synthesis of biaryl compounds with trifluoromethylthio groups. It is also employed in nucleophilic aromatic substitutions to introduce SCF3 moieties into complex molecules, enhancing their lipophilicity and metabolic stability. Researchers leverage its reactivity in high-value pharmaceutical intermediates and functional material design.

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