Description

4-(Trifluoromethyl)piperidine (CAS No. 657-36-3) is a high-purity fluorinated organic compound with the molecular formula C₆H₁₀F₃N. This versatile heterocyclic amine features a piperidine ring substituted with a trifluoromethyl group at the 4-position, offering unique electronic and steric properties for advanced synthetic applications. Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied as a clear, colorless to pale yellow liquid with a characteristic amine odor. Ideal for pharmaceutical intermediates, agrochemical synthesis, and materials science research, this compound is packaged under inert gas to ensure stability and longevity. Available in quantities ranging from 1g to 1kg with customizable bulk options, each batch is accompanied by comprehensive analytical data including ¹H NMR, ¹³C NMR, and GC-MS spectra.

Properties

• CAS Number: 657-36-3
• Complexity: 104
• IUPAC Name: 4-(trifluoromethyl)piperidine
• InChI: InChI=1S/C6H10F3N/c7-6(8,9)5-1-3-10-4-2-5/h5,10H,1-4H2
• InChI Key: RDRQUUWCJTYHCT-UHFFFAOYSA-N
• Exact Mass: 153.07653381
• Molecular Formula: C6H10F3N
• Molecular Weight: 153.15
• SMILES: C1CNCCC1C(F)(F)F
• Topological: 12
• Monoisotopic Mass: 153.07653381
• Synonyms: 4-(Trifluoromethyl)piperidine, 808-182-0, 657-36-3, 4-Trifluoromethylpiperidine, 4-Trifluoromethyl-piperidine, MFCD00102068, Piperidine, 4-(trifluoromethyl)-, EN300-249793, 4-trifluormethyl-piperidine, 4-trifluoromethyl piperidine, SCHEMBL241551, SCHEMBL250782, SCHEMBL2043195, SCHEMBL2044561, SCHEMBL4194170, DTXSID20215917, ZLRDYCMWMNACHK-UHFFFAOYSA-N, BDBM626119, FD2088, AKOS005063350, CS-W002374, AC-26709, DS-13417, SY025651, 4-(Trifluoromethyl)piperidine, AldrichCPR, DB-001272, T3081, EN300-93067

Application

4-(Trifluoromethyl)piperidine serves as a key building block in medicinal chemistry for the development of bioactive molecules, particularly in CNS-targeting pharmaceuticals due to its ability to enhance blood-brain barrier penetration. The trifluoromethyl group’s strong electron-withdrawing properties make this compound valuable in the synthesis of fluorinated analogs for structure-activity relationship studies. It’s also employed in catalytic systems and as a ligand precursor in transition metal complexes for asymmetric synthesis applications.

Safety and Hazards

GHS Hazard Statements

• H226 (80%): Flammable liquid and vapor [Warning Flammable liquids]
• H314 (40%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H315 (60%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (60%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (60%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P316, P319, P321, P332+P317, P337+P317, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (80%)
• Skin Corr. 1B (40%)
• Skin Irrit. 2 (60%)
• Eye Irrit. 2 (60%)
• STOT SE 3 (60%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.